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Neurology Research International
Volume 2010, Article ID 140379, 4 pages
Clinical Study

Diabetic Neuropathy: A Clinical and Neuropathological Study of 107 Patients

Department of Neurology, New York University School of Medicine, New York, NY 10016, USA

Received 4 February 2010; Revised 24 March 2010; Accepted 27 March 2010

Academic Editor: Vincenzo Di Lazzaro

Copyright © 2010 David S. Younger. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


One hundred seven patients were retrospectively studied from 1992 to 2002 with diabetic neuropathy that underwent peripheral nerve biopsy. Nerve biopsy revealed the underlying histopathology, including cell and humoral-mediated immunological lesions in the majority of patients. When combined with clinical and laboratory studies, nerve biopsy has the potential to assist in the selection of patients who may benefit from immunomodulatory therapy.