Figure 2: Brain region associated with subjective sensation of fatigue. (a) Sagittal (upper) and horizontal (lower) views of statistical parametric maps superimposed on template brains. Adjusted regional cerebral blood flow (rCBF) in medial orbitofrontal cortex (Brodmann’s area 10/11) was significantly correlated with standardized visual analogue scale (VAS) score for fatigue ( , Z-score = 4.65, uncorrected). The cluster consisted of 153 voxels extending from the stereotaxic Talairach coordinates ( , , and ). (b) Adjusted rCBF in left medial orbitofrontal cortex and standardized VAS score for fatigue during the task trials. The bar graphs show adjusted rCBF, and the line graphs show standardized VAS score for fatigue, respectively (mean and SD).