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Neurology Research International
Volume 2011 (2011), Article ID 124256, 13 pages
http://dx.doi.org/10.1155/2011/124256
Review Article

Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche: A Therapeutic Target for Huntington's Disease

1Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Strubergasse 21, 5020 Salzburg, Austria
2Department of Neurology, University of Münster Medical School, 48129 Münster, Germany
3Division of Molecular Neurology, University Hospital Erlangen, 91054 Erlangen, Germany
4Department of Neurology, University of Regensburg, D-93053 Regensburg, Germany

Received 15 November 2010; Accepted 19 February 2011

Academic Editor: T. Ben-Hur

Copyright © 2011 Mahesh Kandasamy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The neural stem cell niches possess the regenerative capacity to generate new functional neurons in the adult brain, suggesting the possibility of endogenous neuronal replacement after injury or disease. Huntington disease (HD) is a neurodegenerative disease and characterized by neuronal loss in the basal ganglia, leading to motor, cognitive, and psychological disabilities. Apparently, in order to make use of the neural stem cell niche as a therapeutic concept for repair strategies in HD, it is important to understand the cellular and molecular composition of the neural stem cell niche under such neurodegenerative conditions. This paper mainly discusses the current knowledge on the regulation of the hippocampal neural stem cell niche in the adult brain and by which mechanism it might be compromised in the case of HD.