Mesenchymal Stem Cell Therapy Modulates the Inflammatory Response in Experimental Traumatic Brain Injury

Figure 1

Relative expression of IL-6, TNF-α, IL-10, and IL-4 in acute and chronic models of motor cortex injury. (a) 24 hours and (b) 30 days after injury and MSC injection, RNA was extracted from motor cortex of control, injury without treatment and MSC treated mice. qPCR was performed to quantify the expression of inflammatory cytokines and relative expression was calculated in relation to HPRT. Data are expressed as mean of 2^−ΔΔCt  ± SEM (control 𝑛=3, injury no treatment 𝑛=6, MSC treated 𝑛=4). ^∗𝑃<.05, ^∗∗𝑃<.001, ^∗∗∗𝑃<.0001.

(a)

(b)