Subarachnoid Transplant of the Human Neuronal hNT2.19 Serotonergic Cell Line Attenuates Behavioral Hypersensitivity without Affecting Motor Dysfunction after Severe Contusive Spinal Cord Injury
Figure 9
Open-field motor behaviors (BBB) and graft of hNT2.19 or hNT2.6 cells in severe contusive SCI. Gross open-field motor behavioral results show gradual recovery of motor scores beginning at 1 week after SCI, with no additional recovery with the addition of hNT2.19 or hNT2.6 grafts. Data represent the mean value + SEM ( animals in each group) at each time point for 56 days after SCI. BBB scores did not improve over the natural history of recovery after SCI, when either cell line was grafted into the subarachnoid space. Laminectomy alone had no effect on normal BBB scores, and addition of hNT2.19 or hNT2.6 grafted cells to laminectomy animals was not different from laminectomy alone. The hNT2.19 cell therapy, when cells are transplanted into the lumbar subarachnoid space, has no effect on open-field motor behaviors, with or without severe contusive SCI.
