Subarachnoid Transplant of the Human Neuronal hNT2.19 Serotonergic Cell Line Attenuates Behavioral Hypersensitivity without Affecting Motor Dysfunction after Severe Contusive Spinal Cord Injury
Table 1
(a) ANOVA showing tactile allodynia thresholds, (b) Post hoc tests for tactile allodynia (Bonferroni corrected values shown).
(a)
Time after contusion
Group 1: laminectomy
Group 2: contusion
Group 3: contusion + hNT2-6
Group 4: contusion + hNT2-19
Group 5: laminectomy + hNT-19
Group 6: laminectomy + hNT2-6
One way ANOVA
Mean (SEM)
Mean (SEM)
Mean (SEM)
Mean (SEM)
Mean (SEM)
Mean (SEM)
-statistic, value
Baseline
34.2 (0.13)a
34.8 (0.24)b
34.8 (0.1)c
34.8 (0.23)d
34.6 (0.16)e
34.7 (0.28)f
1.03,
7
34.0 (0.51)a
17.8 (1.45)b
NA
NA
NA
NA
81.9,
14 (10)*
34.5 (0.26)a
16.8 (1.52)b
17.3 (0.81)c
17.6 (0.62)d
34.8 (0.17)e
35.4 (0.39)f
175.9,
21
34.5 (0.28)a
15.9 (0.86)b
18.1 (0.91)c
27.2 (0.98)d
34.2 (0.18)e
34.5 (0.29)f
139.2,
28
34.5 (0.15)a
16.4 (0.74)b
16.8 (0.61)c
28.4 (0.60)d
34.0 (0.28)e
34.4 (0.27)f
264.4,
35
34.9 (0.14)a
16.6 (0.79)b
17.2 (0.63)c
29.8 (0.48)d
34.1 (0.10)e
35.0 (0.14)f
302.5,
42
34.4 (0.17)a
16.7 (0.56)b
16.8 (0.80)c
31.0 (0.59)d
34.7 (0.44)e
34.8 (0.28)f
282.0,
49
34.8 (0.28)a
17.0 (0.64)b
17.2 (1.09)c
31.1 (0.25)d
33.4 (0.40)e
33.7 (0.27)f
217.2,
56
34.9 (0.11)a
17.0 (0.50)b
16.7 (0.99)c
32.2 (0.47)d
34.0 (0.14)e
34.1 (0.26)f
291.8,
*Time after contusion is 10 days for groups 2, 3, 4 and 14 days for 1, 6, and 7. Post hoc analyses (Bonferroni):
aGroup 1 is significantly different than Groups 2, 3, 4 on all time points.
bGroup 2 is significantly different than Groups 1, 4, 5, 6 at all time points except for when it is not significantly different from group 4.
cGroup 3 is significantly different than Groups 1, 4, 5, 6 at all time points except for when it is not significantly different from group 4.
dGroup 4 is significantly different from all groups on times 21, 28, 35, 42; : significantly different from groups 1, 5, 6; : all but group 5; : all but 5 and 6.
eGroup 5 is significantly different from groups 2, 3, 4 on all time points except at and where group 5 is significantly different only from groups 2 and 3.
fGroup 6 is significantly different from groups 2, 3, 4 on all time points except at where group 5 is significantly different from 2 and 3 only.
