|
Protein | Model | Technique | Function in neurogenesis | References |
|
EGF | Intact | Infusion into the lateral ventricle using an osmotic pump | Proliferation of SVZ progenitors (18-fold increase compared with saline infusion group) | [69] |
Intact | Infusion into the lateral ventricle using an osmotic pump | Proliferation of SVZ progenitors (9.5-fold increase compared with aCSF infusion group) | [70] |
MCAO | Overexpression in the SVZ | Proliferation of SVZ progenitors (1.7-fold increase compared with control vector treatment group) | [64] |
|
FGF-2 | Intact | Infusion into the lateral ventricle using an osmotic pump | Proliferation of SVZ progenitors (2.4-fold increase compared with serum albumin infusion group) | [69] |
Intact | Infusion into the lateral ventricle using an osmotic pump | Proliferation of SVZ progenitors (3.3-fold increase compared with aCSF infusion group) | [70] |
MCAO | Infusion into the cisterna magna | Proliferation of SVZ progenitors (increase compared with vehicle treatment group) | [65] |
|
Angiopoietin 2 | 6-OHDA | Infusion into the lateral ventricle | Proliferation of SVZ progenitors (increase compared with BSA treatment group) | [71] |
|
TGF-α | Intact | Infusion into the lateral ventricle using an osmotic pump | Proliferation of SVZ progenitors (14-fold increase compared with albmin infusion group) | [69] |
6-OHDA | Infusion into the striatum using an osmotic pump | Proliferation of SVZ progenitors (increase compared with PBS infusion group) | [72] |
6-OHDA | Infusion into the striatum using an osmotic pump | Generation of neurons in the striatum (immature neuron, increase compared with aCSF infusion group) | [73] |
|
GDNF | MCAO | Infusion into the striatum using an osmotic pump | Generation of neurons in the striatum (immature neuron, 1.86-fold; mature neuron, 1.2-fold, increase compared with PBS treatment group) | [66] |
|
SDF-1α | HI | | Migration of implanted hNSCs toward the injured area in ischemic brain slice (increase) | [57] |
|
Tenascin-R | Intact | Tenascin-R expressing cell implantation into the striatum | Migration of SVZ new neurons toward the striatum (4-fold increase compared with the Tenascin nonexpression cell implanted group) | [74] |
Quinolic acid | TNR-expressing ESCs implantation into the striatum | Migration of SVZ new neurons into the striatum (increase compared with TNR-nonexpression ESCs implanted group) | [75] |
|
BDNF | Intact | Infusion into the lateral ventricle using an osmotic pump | Generation of neurons in the OB (increase compared with PBS infusion group) | [76] |
Intact | Infusion into the lateral ventricle using an osmotic pump | Generation of neurons in the striatum (increase compared with PBS infusion group) | [77] |
R6/2 | Overexpression in the SVZ | Generation of neurons in the striatum (21-fold increase compared with saline group) | [68] |
|