Administration of Recombinant Heat Shock Protein 70 Delays Peripheral Muscle Denervation in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis
Figure 4
rhHsp70 slows axon atrophy in the tibial branch of the sciatic nerve. (a) There was no difference in the overall number of myelinated axons in the tibial branch of the sciatic nerve at P30 or P75. Data are represented as percent of WT SEM at each time point; each group. Statistical significance was determined as previously described. (b) Size profiles of the axon area at P30 revealed that there are comparable numbers of larger myelinated axons between WT and SOD1-untreated animals. Axon area and statistical significance were determined as previously described. (c) Axon area analysis determined that only WT animals had a greater number of larger myelinated axons in the tibial branch of the sciatic nerve at P75 (*). Axon area and statistical significance were determined as previously described. Axon area was determined as previously described.
