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Neurology Research International
Volume 2012, Article ID 478560, 13 pages
http://dx.doi.org/10.1155/2012/478560
Research Article

A Novel Mathematical Approach to Define the Genes/SNPs Conferring Risk or Protection in Sporadic Amyotrophic Lateral Sclerosis Based on Auto Contractive Map Neural Networks and Graph Theory

1Semeion Research Center, Via Sersale 117, 00128 Rome, Italy
2Medical Genetics, Department of Laboratory Medicine, Niguarda Ca' Granda Hospital Piazzaza Ospedale Maggiore 3, 20100 Milan, Italy
3Medical Department, Bracco SpA, Via E. Folli 50, 20134 Milan, Italy

Received 23 January 2012; Accepted 5 April 2012

Academic Editor: Changiz Geula

Copyright © 2012 Massimo Buscema et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Buscema, “A novel adapting mapping method for emergent properties discovery in data bases:experience in medical field,” in Proceedings of the IEEE International Conference on Systems, Man and Cybernetics (SMC '07), Montreal, Canada, October 2007.
  2. R. Tandan and W. G. Bradley, “Amyotrophic lateral sclerosis: part I. Clinical features, pathology, and ethical issues in management,” Annals of Neurology, vol. 18, no. 3, pp. 271–280, 1985. View at Google Scholar · View at Scopus
  3. R. G. Miller, J. D. Mitchell, M. Lyon, and D. H. Moore, “Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND),” Cochrane Database of Systematic Reviews, no. 1, Article ID CD001447, 2007. View at Google Scholar · View at Scopus
  4. A. Beleza-Meireles and A. Al-Chalabi, “Genetic studies of amyotrophic lateral sclerosis: controversies and perspectives,” Amyotrophic Lateral Sclerosis, vol. 10, no. 1, pp. 1–14, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. J. J. P. Perry, D. S. Shin, and J. A. Tainer, “Amyotrophic lateral sclerosis,” Advances in Experimental Medicine and Biology, vol. 685, pp. 9–20, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Penco, M. Buscema, M. Patrosso, A. Marocchi, and E. Grossi, “New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background,” BMC Bioinformatics, vol. 9, p. 254, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Buscema, Ed., “Squashing theory and contractive map network,” Semeion Technical Paper 32, 2007. View at Google Scholar
  8. M. Buscema, C. Helgason, and E. Grossi, “Auto contractive maps, H function and maximally regular graph: theory and applications,” in Proceedings of the IEEE Special Session on Artificial Adaptive Systems in Medicine: applications in the real world (NAFIPS '08), New York, NY, USA, May 2008.
  9. M. Buscema and E. Grossi, Eds., Artificial Adaptive Systems in Medicine, eBooks-Bentham Science Publishers, Oak Park, Ill, USA, 2009.
  10. B. Kruskal, “On the shortest spanning subtree of a graph and the traveling salesman problem,” Proceedings of the American Mathematical Society, vol. 7, no. 1, pp. 48–50, 1956. View at Google Scholar
  11. D. R. Karger, P. N. Klein, and R. E. Tarjan, “Randomized linear-time algorithm to find minimum spanning trees,” Journal of the ACM, vol. 42, no. 2, pp. 321–328, 1995. View at Publisher · View at Google Scholar · View at Scopus
  12. A.-L. Barabási, “Network medicine-from obesity to the ‘Diseasome’,” New England Journal of Medicine, vol. 357, no. 4, pp. 404–407, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Massini, Tree Visualizer, Semeion Software #40, ver. 8.0, 2006–2011, Rome.
  14. T. Vowinkel, M. Mori, C. F. Krieglstein et al., “Apolipoprotein A-IV inhibits experimental colitis,” Journal of Clinical Investigation, vol. 114, no. 2, pp. 260–269, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Lu, M. E. T. Dollé, S. Imholz et al., “Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations,” Journal of Lipid Research, vol. 49, no. 12, pp. 2582–2589, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Dupuis, P. Corcia, A. Fergani et al., “Dyslipidemia is a protective factor in amyotrophic lateral sclerosis,” Neurology, vol. 70, no. 13, pp. 1004–1009, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Chiò, A. Calvo, A. Ilardi et al., “Lower serum lipid levels are related to respiratory impairment in patients with ALS,” Neurology, vol. 73, no. 20, pp. 1681–1685, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Siciliano, C. D'Avino, A. Del Corona et al., “Impaired oxidative metabolism and lipid peroxidation in exercising muscle from ALS patients,” Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, vol. 3, no. 2, pp. 57–62, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Baillet, V. Chanteperdrix, C. Trocmé, P. Casez, C. Garrel, and G. Besson, “The role of oxidative stress in amyotrophic lateral sclerosis and Parkinson's disease,” Neurochemical Research, vol. 35, no. 10, pp. 1530–1537, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. M. Fan, O. T. Raitakari, M. Kähönen et al., “Hepatic lipase promoter C-480T polymorphism is associated with serum lipids levels, but not subclinical atherosclerosis: the Cardiovascular Risk in Young Finns Study,” Clinical Genetics, vol. 76, no. 1, pp. 46–53, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. P. A. McCaskie, G. Cadby, J. Hung et al., “The C-480T hepatic lipase polymorphism is associated with HDL-C but not with risk of coronary heart disease,” Clinical Genetics, vol. 70, no. 2, pp. 114–121, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Stemmelin, C. Cohen, I. Yalcin, P. Keane, and G. Griebel, “Implication of β3-adrenoceptors in the antidepressant-like effects of amibegron using Adrb3 knockout mice in the chronic mild stress,” Behavioural Brain Research, vol. 206, no. 2, pp. 310–312, 2010. View at Publisher · View at Google Scholar
  23. H. Kadowaki, K. Yasuda, K. Iwamoto et al., “A mutation in the β3-adrenergic receptor gene is associated with obesity and byperinsulinemia in Japanese subjects,” Biochemical and Biophysical Research Communications, vol. 215, no. 2, pp. 555–560, 1995. View at Publisher · View at Google Scholar
  24. C. Santiago, J. R. Ruiz, A. Buxens et al., “Trp64Arg polymorphism in ADRB3 gene is associated with elite endurance performance,” British Journal of Sports Medicine, vol. 45, no. 2, pp. 147–149, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. O. Piazza, A. L. Sirén, and H. Ehrenreich, “Soccer, neurotrauma and amyotrophic lateral sclerosis: is there a connection?” Current Medical Research and Opinion, vol. 20, no. 4, pp. 505–508, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. E. Beghi, G. Logroscino, A. Chiò et al., “Amyotrophic lateral sclerosis, physical exercise, trauma and sports: results of a population-based pilot case-control study,” Amyotrophic Lateral Sclerosis, vol. 11, no. 3, pp. 289–292, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Renaud and D. Leppert, “Matrix metalloproteinases in neuromuscular disease,” Muscle and Nerve, vol. 36, no. 1, pp. 1–13, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. I. Choi, Y. In Yang, H.D. Song et al., “Lipid molecules induce the cytotoxic aggregation of Cu/Zn superoxide dismutase with structurally disordered regions,” Biochimica et Biophysica Acta, vol. 1812, no. 1, pp. 41–48, 2011. View at Publisher · View at Google Scholar
  29. A. Chiò, A. Calvo, A. Ilardi et al., “Lower serum lipid levels are related to respiratory impairment in patients with ALS,” Neurology, vol. 73, no. 20, pp. 1681–1685, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Panov, N. Kubalik, B. R. Brooks, and C. A. Shaw, “In vitro effects of cholesterol β-d-glucoside, cholesterol and cycad phytosterol glucosides on respiration and reactive oxygen species generation in brain mitochondria,” Journal of Membrane Biology, vol. 237, no. 2-3, pp. 71–77, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. R. M. Adibhatla and J. F. Hatcher, “Altered lipid metabolism in brain injury and disorders,” Sub-Cellular Biochemistry, vol. 49, pp. 241–268, 2008. View at Google Scholar · View at Scopus
  32. M. Valenza and E. Cattaneo, “Cholesterol dysfunction in neurodegenerative diseases: is Huntington's disease in the list?” Progress in Neurobiology, vol. 80, no. 4, pp. 165–176, 2006. View at Publisher · View at Google Scholar · View at Scopus