Research Article

A Novel Mathematical Approach to Define the Genes/SNPs Conferring Risk or Protection in Sporadic Amyotrophic Lateral Sclerosis Based on Auto Contractive Map Neural Networks and Graph Theory

Table 1

The Delta H function with the relative hubness into the Controls and Cases datasets.

Control
VariablesHub relevanceVariablesHub relevance

Global0.17193
NOS3_C_690_T
0.171429
ADRB3_trp64arg0.136905NOS3_glu298asp
0.171429
LIPC_C_480_T0.136905DCP1_ins_del0.171429
MMP3_5A_6A0.136905AGTR1_A1166C
0.171429
APOC3_C_641_A0.171429AGT_met235thr
0.171429
APOC3_C_482_T0.171429NPPA_G664A
0.171429
APOC3_T_455_C0.171429NPPA_T2238C
0.171429
APOC3_C1100T0.171429ADD1_gly460trp
0.171429
APOC3_C3175G0.171429SCNN1_trp493arg
0.171429
APOC3_T3206G0.171429SCNN1A_ala663thr
0.171429
APOE_cys112arg0.171429GNB3_C825T
0.171429
APOE_arg158cys0.171429ADRB2_arg16gly
0.171429
APOA4_thr347ser0.171429ADRB2_gln27glu
0.171429
PPARG_pro12ala0.171429APOB_thr71ile
0.171429
APOA4_glu360his0.171429F2_G20210A
0.171429
LPL_T_93_G0.171429F5_arg506gln
0.171429
LPL_asp9asn0.171429F7_del_ins
0.171429
LPL_asn291ser0.171429F7_arg353glu
0.171429
LPL_ser447term0.171429PAI_G5_G4
0.171429
PON1_met55leu0.171429PAI_G11053T
0.171429
PON1_gln192arg0.171429FGB_G_455_A
0.171429
PON2_ser311cys0.171429ITGA2_G873A
0.171429
LDLR_Ncol_Ncol0.171429ITGB3_leu33pro
0.171429
CETP_6300.171429SELE_ser128arg
0.171429
CETP_6280.171429SELE_leu554phe
0.171429
CETP_ile405val0.171429ICAM_gly214arg
0.171429
LTA_thr26asn_A0.171429TNFa_G_376_A
0.171429
MTHFR_C677T0.171429TNFa_G_308_A
0.171429
NOS3_A_922_G0.171429TNFa_244
0.171429
TNFa_238
0.171429
LTA_thr26asn_B
0.171429

Cases
Variables
Hub relevance
Variables
Hub relevance

Global
0.137127AGTR1_A1166C
0.136905
APOA4_thr347ser
0.136905
AGT_met235thr
0.136905
APOB_thr71ile
0.136905NPPA_G664A
0.136905
APOC3_C_641_A
0.136905NPPA_T2238C
0.136905
APOC3_C_482_T
0.136905ADD1_gly460trp
0.136905
APOC3_T_455_C
0.136905SCNN1_trp493arg
0.136905
APOC3_C1100T
0.136905SCNN1A_ala663thr
0.136905
APOC3_C3175G
0.136905GNB3_C825T
0.136905
APOC3_T3206G
0.136905ADRB2_arg16gly
0.136905
APOE_cys112arg
0.136905ADRB2_gln27glu
0.136905
APOE_arg158cys
0.136905MMP3_5A_6A
0.136905
ADRB3_trp64arg
0.136905F2_G20210A
0.136905
PPARG_pro12ala
0.136905F5_arg506gln
0.136905
LIPC_C_480_T
0.136905F7_del_ins
0.136905
LPL_T_93_G
0.136905F7_arg353glu
0.136905
LPL_asp9asn
0.136905PAI_G5_G4
0.136905
LPL_asn291ser
0.136905PAI_G11053T
0.136905
PON1_met55leu
0.136905FGB_G_455_A
0.136905
PON1_gln192arg
0.136905ITGA2_G873A
0.136905
PON2_ser311cys
0.136905ITGB3_leu33pro
0.136905
LDLR_NcoI_NcoI
0.136905SELE_ser128arg
0.136905
CETP_630
0.136905SELE_leu554phe
0.136905
CETP_628
0.136905ICAM_gly214arg
0.136905
CETP_ile405val
0.136905TNFa_G_376_A
0.136905
LTA_thr26asn_A
0.136905TNFa_G_308_A
0.136905
MTHFR_C677T
0.136905TNFa_244
0.136905
NOS3_C_690_T
0.136905TNFa_238
0.136905
NOS3_glu298asp
0.136905LTA_thr26asn_B
0.136905
DCP1_ins_del
0.136905APOA4_glu360his
0.171429
NOS3_A_922_G
0.171429
LPL_ser447term
0.171429