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Neurology Research International
Volume 2012, Article ID 502096, 7 pages
Clinical Study

Motor Cortex Stimulation in Parkinson's Disease

1Department of Neurosurgery, University Hospital of Germaneto, Campus “Salvatore Venuta”, Viale Europa, 88100 Catanzaro, Italy
2Department of Neurology, General Hospital, Crotone, Italy
3Department of Psychiatry, University Hospital of Mater Domini, Catanzaro, Italy

Received 1 July 2012; Revised 29 August 2012; Accepted 2 October 2012

Academic Editor: Nader Pouratian

Copyright © 2012 Marisa De Rose et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Motor Cortex Stimulation (MCS) is less efficacious than Deep Brain Stimulation (DBS) in Parkinson's disease. However, it might be proposed to patients excluded from DBS or unresponsive to DBS. Ten patients with advanced PD underwent unilateral MCS contralaterally to the worst clinical side. A plate electrode was positioned over the motor cortex in the epidural space through single burr hole after identification of the area with neuronavigation and neurophysiological tests. Clinical assessment was performed by total UPDRS, UPDRS III total, UPDRS III-items 27–31, UPDRS IV, and UPDRS II before implantation in off-medication and on-medication states and after surgery at 1, 3, 6, 12, 18, 24, and 36 months in on-medication/on-stimulation and off-medication/on-stimulation states. We assessed changes of quality of life, throughout the Parkinson's disease quality of life scale (PDQoL-39), and the dose of anti-Parkinson's disease medications, throughout the Ldopa equivalent daily dose (LEDD). During off-medication state, we observed moderate and transitory reduction of total UPDRS and UPDRS total scores and significant and long-lasting improvement in UPDRS III items 27–31 score for axial symptoms. There was marked reduction of UPDRS IV score and LEDD. PDQL-39 improvement was also significant. No important complications and adverse events occurred.