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Neurology Research International
Volume 2012 (2012), Article ID 628949, 7 pages
Clinical Study

Recurrent CSPs after Transcranial Magnetic Stimulation of Motor Cortex in Restless Legs Syndrome

1Forensic Psychiatry, National Institute for Health and Welfare, P.O. Box 30, 00271 Helsinki, Finland
2Psychiatric Hospital for Prisoners, P.O. Box 49, 20251 Turku, Finland
3BioMag Laboratory, Helsinki University Central Hospital (HUCH), P.O. Box 340, 00029, Helsinki, Finland
4Neuropsychiatric Outpatient Clinic and the Sleep Research Unit, Turku University Hospital, University of Turku, P.O. Box 52, 20521 Turku, Finland
5Department of Clinical Neurophysiology, Helsinki University Central Hospital, P.O. Box 1020, 10601 Helsinki, Finland
6Institute of Biomedical Engineering, Tampere University of Technology, 33101 Tampere, Finland

Received 21 August 2012; Revised 20 October 2012; Accepted 20 October 2012

Academic Editor: Mamede de Carvalho

Copyright © 2012 Aulikki Ahlgrén-Rimpiläinen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aims. The aim of this study was to investigate the motor control and central silent period (CSP) in restless legs syndrome (RLS). Methods. Transcranial magnetic stimulation was focused on the dominant and nondominant hemispheric areas of motor cortex in six subjects with RLS and six controls. The responses were recorded on the contralateral abductor digiti minimi (ADM) and tibialis anterior (TA) muscles with intramuscular needle electrodes. Results. No significant differences were found in the motor conduction or central motor conduction time, in the latency, or in the duration of the CSPs between or within the groups, but multiple CSPs were observed in both groups. The number of the CSPs was significantly higher in both ADMs and in the dominant TA ( ) in the RLS group compared to the controls. Conclusion. Descending motor pathways functioned correctly in both groups. The occurrence of the recurrent CSPs predominantly in the RLS group could be a sign of a change of function in the inhibitory control system. Further research is needed to clarify the role of the intramuscular recording technique and especially the role of the subcortical generators in the feedback regulation of the central nervous system in RLS.