Review Article
The Neuroinflammatory Response in ALS: The Roles of Microglia and T Cells
Table 2
The categorization of T cells into subsets is based on cell antigenicity, cytokine profile, and effector function.
| | Antigenicity | Cytokine profile | Effector function |
| Th1 | CD4+ | IL-2, TNF-α, IFN-γ | M1 macrophage activation | Th2 | CD4+ | IL-4, IL-10, IL-6, IL-13 | Downregulation of M1 macrophage activation | Th17 | CD4+ | IL-17 | M1 macrophage activation | Treg | CD4+CD25+FoxP3+ | IL-4, IL-10, TGF-β | Damping of proinflammatory response | CTL | CD8+ | TNF-α, IFN-γ | Elimination of infected cells |
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