Multimodal MRI Neuroimaging Biomarkers for Cognitive Normal Adults, Amnestic Mild Cognitive Impairment, and Alzheimer's Disease

Figure 8

Patterns of GMV loss in MCI and normal aging. Average slopes of RAVENS maps for normal (a) and MCI (b) groups. The red-yellow color indicates greater volume loss. Bottom row: difference between the two groups; blue/green are regions in which MCI subjects showed higher rate of gray matter decrease. (c) Red/yellow colors reflect an increase of periventricular small vessel disease, which appears gray in T1-weighted images and is segmented as gray matter. The color bars display estimated regression coefficients and are defined by the following numbers, all in mm³/year (per voxel in the template space): a=−0.020, b=−0.0053, c=0.026, d=0.0053, e=−0.0053, and f=−0.023 (adapted with permission from [35]).

(a)

(b)

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