Table of Contents Author Guidelines Submit a Manuscript
Neurology Research International
Volume 2013, Article ID 293893, 11 pages
http://dx.doi.org/10.1155/2013/293893
Review Article

Mitochondrial Fusion Proteins and Human Diseases

1Dino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, Neurology Unit, IRCCS Foundation Ca’ Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy
2IRCCS Eugenio Medea, Bosisio Parini, 23842 Lecco, Italy

Received 15 February 2013; Revised 28 April 2013; Accepted 1 May 2013

Academic Editor: Mamede de Carvalho

Copyright © 2013 Michela Ranieri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [53 citations]

The following is the list of published articles that have cited the current article.

  • Susana Ponte, Lara Carvalho, Maria Gagliardi, Isabel Campos, Paulo J. Oliveira, and António Jacinto. View at Publisher · View at Google Scholar
  • Chandrakumar Balaratnasingam, William H. Morgan, Er-Ning Su, Paula K. Yu, Dao-Yi Yu, and Stephen J. Cringle, “Retinal ganglion cells: Energetics, compartmentation, axonal transport, cytoskeletons and vulnerability,” Progress In Retinal And Eye Research, vol. 36, pp. 217–246, 2013. View at Publisher · View at Google Scholar
  • Mansi Babbar, and Saeed Sheikh, “Metabolic stress and disorders related to alterations in mitochondrial fission or fusion,” Molecular and Cellular Pharmacology, vol. 5, no. 3, pp. 109–133, 2013. View at Publisher · View at Google Scholar
  • Azhub I. Gaziev, Serzh Abdullaev, and Andrej Podlutsky, “Mitochondrial function and mitochondrial DNA maintenance with advancing age,” Biogerontology, 2014. View at Publisher · View at Google Scholar
  • Cheng Chen, Yun Wang, Juan Zhang, Lian Ma, Jiang Gu, and Guyu Ho, “Contribution of neural cell death to depressive phenotypes of streptozotocin-induced diabetic mice,” Disease Models & Mechanisms, vol. 7, no. 6, pp. 723–730, 2014. View at Publisher · View at Google Scholar
  • Terence Gordon Smith, and Marcela Votruba, “Inherited dominant optic neuropathy: from clinical studies to gene function and back again,” Drug Discovery Today: Disease Models, 2014. View at Publisher · View at Google Scholar
  • Philippe Delmotte, and Gary C. Sieck, “ Interaction between endoplasmic/sarcoplasmic reticulum stress (ER/SR stress), mitochondrial signaling and Ca 2+ regulation in airway smooth muscle (ASM) 1 ,” Canadian Journal of Physiology and Pharmacology, pp. 1–14, 2014. View at Publisher · View at Google Scholar
  • Xuchen Zhang, Peiying Shan, Robert Homer, Yi Zhang, Irina Petrache, Praveen Mannam, and Patty J. Lee, “Cathepsin E Promotes Pulmonary Emphysema via Mitochondrial Fission,” The American Journal of Pathology, vol. 184, no. 10, pp. 2730–2741, 2014. View at Publisher · View at Google Scholar
  • José Marín-García, “The Emerging Role of Mitochondrial Dynamics in Cardiovascular Disease,” Post-Genomic Cardiology, pp. 499–530, 2014. View at Publisher · View at Google Scholar
  • Selena Kazancioglu, Mike Gerards, Suzanne Buckley, Eero Lihavainen, Howard T. Jacobs, Giuseppe Cannino, Filippo Scialo, Andre Ribeiro, Eric Dufour, and Atsushi Fukuoh, “Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase,” Molecular Systems Biology, vol. 10, no. 6, 2014. View at Publisher · View at Google Scholar
  • Jian Gong, Ming Hu, Wei Wu, and Yanhui Li, “The interventional effect of Xuebijing injection on expression of mitochondrial fusion protein 2 and the ultrastructure changes in lung tissues in rats with paraquat poisoning,” Chinese Critical Care Medicine, vol. 26, no. 6, pp. 388–393, 2014. View at Publisher · View at Google Scholar
  • Bumsup Kwon, Timothy Gamache, Han-Kyu Lee, and Henry W. Querfurth, “Synergistic effects of β-amyloid and ceramide-induced insulin resistance on mitochondrial metabolism in neuronal cells,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1852, no. 9, pp. 1810–1823, 2015. View at Publisher · View at Google Scholar
  • Giovanni Manfredi, and Hibiki Kawamata, “Mitochondria and endoplasmic reticulum crosstalk in amyotrophic lateral sclerosis,” Neurobiology of Disease, 2015. View at Publisher · View at Google Scholar
  • Naghia Ahmed, Dario Ronchi, and Giacomo Pietro Comi, “Genes and pathways involved in adult onset disorders featuring muscle mitochondrial DNA instability,” International Journal of Molecular Sciences, vol. 16, no. 8, pp. 18054–18076, 2015. View at Publisher · View at Google Scholar
  • Giulia Stuppia, Federica Rizzo, Giulietta Riboldi, Roberto Del Bo, Monica Nizzardo, Chiara Simone, Giacomo P. Comi, Nereo Bresolin, and Stefania Corti, “MFN2-related neuropathies: Clinical features, molecular pathogenesis and therapeutic perspectives,” Journal of the Neurological Sciences, 2015. View at Publisher · View at Google Scholar
  • S. Baltrusch, F. Reinhardt, and M. Tiedge, “Mitochondrien als Kraftwerk der β-Zelle,” Der Diabetologe, vol. 11, no. 3, pp. 231–242, 2015. View at Publisher · View at Google Scholar
  • Daniel José Barbosa, João Paulo Capela, Rita Feio-Azevedo, Armanda Teixeira-Gomes, Maria de Lourdes Bastos, and Félix Carvalho, “Mitochondria: key players in the neurotoxic effects of amphetamines,” Archives of Toxicology, 2015. View at Publisher · View at Google Scholar
  • Surinder Kumar, and David B. Lombard, “Mitochondrial Sirtuins and Their Relationships with Metabolic Disease and Cancer,” Antioxidants & Redox Signaling, pp. 150210135716004, 2015. View at Publisher · View at Google Scholar
  • Chloé Di Meglio, Nathalie Bonello-Palot, Christophe Boulay, Mathieu Milh, Caroline Ovaert, Nicolas Levy, and Brigitte Chabrol, “Clinical and allelic heterogeneity in a pediatric cohort of 11 patients carrying MFN2 mutation,” Brain and Development, 2015. View at Publisher · View at Google Scholar
  • Thomas H. Sanderson, Sarita Raghunayakula, and Rita Kumar, “Release of Mitochondrial Opa1 following Oxidative Stress in HT22 cells,” Molecular and Cellular Neuroscience, 2015. View at Publisher · View at Google Scholar
  • Khushbu Jain, Dipti Prasad, Shashi Bala Singh, and Ekta Kohli, “Hypobaric Hypoxia Imbalances Mitochondrial Dynamics in Rat Brain Hippocampus,” Neurology Research International, vol. 2015, pp. 1–12, 2015. View at Publisher · View at Google Scholar
  • Emmanuel D. Williams, Xiaomin Zhang, Gohar Azhar, Steven C. Rogers, and Jeanne Y. Wei, “Does p49/STRAP, a SRF-binding protein (SRFBP1), modulate cardiac mitochondrial function in aging?,” Experimental Gerontology, vol. 82, pp. 150–159, 2016. View at Publisher · View at Google Scholar
  • Federica Rizzo, Dario Ronchi, Sabrina Salani, Monica Nizzardo, Francesco Fortunato, Andreina Bordoni, Giulia Stuppia, Roberto Del Bo, Daniela Piga, Romana Fato, Nereo Bresolin, Giacomo P. Comi, and Stefania Corti, “Selective mitochondrial depletion, apoptosis resistance, and increased mitophagy in human Charcot-Marie-Tooth 2A motor neurons,” Human Molecular Genetics, pp. ddw258, 2016. View at Publisher · View at Google Scholar
  • Sanjay Kumar, Christopher C. Pan, Nirav Shah, Sarah E. Wheeler, Kari R. Hoyt, Nadine Hempel, Karthikeyan Mythreye, and Nam Y. Lee, “Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion,” Molecular Cell, 2016. View at Publisher · View at Google Scholar
  • Jose Marin-Garcia, and Alexander T. Akhmedov, “Mitochondrial dynamics and cell death in heart failure,” Heart Failure Reviews, vol. 21, no. 2, pp. 123–136, 2016. View at Publisher · View at Google Scholar
  • Yuan Yang, and Ling Li, “A novel p.Val244Leu mutation in MFN2 leads to Charcot-Marie-Tooth disease type 2,” Italian Journal of Pediatrics, vol. 42, no. 1, 2016. View at Publisher · View at Google Scholar
  • Qiu-Lei Xi, Ying Chen, Yu-Song Han, Qiu-Lin Zhuang, Hai-Yu Wang, Jing Fang, Guo-Hao Wu, Bo Zhang, Yi Jiang, Hai-Sheng Zhang, Qing-Yang Meng, and Jun Han, “Mitofusin-2 prevents skeletal muscle wasting in cancer cachexia,” Oncology Letters, vol. 12, no. 5, pp. 4013–4020, 2016. View at Publisher · View at Google Scholar
  • Daniel José Barbosa, João Paulo Capela, Maria de Lourdes Bastos, and Félix Carvalho, “Mitochondrial Trails in the Neurotoxic Mechanisms of MDMA,” Neuropathology of Drug Addictions and Substance Misuse, pp. 431–444, 2016. View at Publisher · View at Google Scholar
  • Wang Wang, Celia Fernandez-Sanz, and Shey-Shing Sheu, “Regulation of mitochondrial bioenergetics by the non-canonical roles of mitochondrial dynamics proteins in the heart,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017. View at Publisher · View at Google Scholar
  • Martijn Kerkhofs, Carlotta Giorgi, Saverio Marchi, Bruno Seitaj, Jan B. Parys, Paolo Pinton, Geert Bultynck, and Mart Bittremieux, “Alterations in Ca2+ Signalling via ER-Mitochondria Contact Site Remodelling in Cancer,” Organelle Contact Sites, vol. 997, pp. 225–254, 2017. View at Publisher · View at Google Scholar
  • Aakruti Arun Kaikini, Urvi Narayan Nerurkar, Sadhana Sathaye, and Divya Manohar Kanchan, “Targeting mitochondrial dysfunction for the treatment of diabetic complications: Pharmacological interventions through natural products,” Pharmacognosy Reviews, vol. 11, no. 22, pp. 128–135, 2017. View at Publisher · View at Google Scholar
  • Jonathan C. Vacek, Jyotirmaya Behera, Akash K. George, Pradip K. Kamat, Anuradha Kalani, and Neetu Tyagi, “Tetrahydrocurcumin ameliorates homocysteine-mediated mitochondrial remodeling in brain endothelial cells,” Journal of Cellular Physiology, 2017. View at Publisher · View at Google Scholar
  • Gursimran Chandhok, Michael Lazarou, and Brent Neumann, “Structure, function, and regulation of mitofusin-2 in health and disease,” Biological Reviews, 2017. View at Publisher · View at Google Scholar
  • Yu-Lu Cao, Shuxia Meng, Yang Chen, Jian-Xiong Feng, Dong-Dong Gu, Bing Yu, Yu-Jie Li, Jin-Yu Yang, Shuang Liao, David C. Chan, and Song Gao, “MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion,” Nature, 2017. View at Publisher · View at Google Scholar
  • Hisao Yamamura, Yoshiaki Suzuki, and Yuji Imaizumi, “Physiological roles of mitochondria and mitofusins on Ca2+ signaling in smooth muscles,” Folia Pharmacologica Japonica, vol. 149, no. 6, pp. 260–263, 2017. View at Publisher · View at Google Scholar
  • Young Jong Kim, Jin Kyung Park, Won Sub Kang, Su Kang Kim, Changsu Han, Hae Ri Na, Hae Jeong Park, Jong Woo Kim, Young Youl Kim, Moon Ho Park, and Jong-Woo Paik, “Association between Mitofusin 2 Gene Polymorphisms and Late-Onset Alzheimer's Disease in the Korean Population,” Psychiatry Investigation, vol. 14, no. 1, pp. 81, 2017. View at Publisher · View at Google Scholar
  • Li Ge, Xue-Er Wang, Zhen Wang, Guo-Hua Song, Ya-Zhuo Xue, Hao-Shen Shi, Ming Yang, Xin-Xin Yin, Wen-Gang Song, Li-Hua Wei, Chang-Qing Du, and Run-Ting Li, “Hydrogen-rich saline attenuates spinal cord hemisectioninduced testicular injury in rats,” Oncotarget, vol. 8, no. 26, pp. 42314–42331, 2017. View at Publisher · View at Google Scholar
  • Jianghui Meng, “Distinct functions of dynamin isoforms in tumorigenesis and their potential as therapeutic targets in cancer,” Oncotarget, vol. 8, no. 25, pp. 41701–41716, 2017. View at Publisher · View at Google Scholar
  • Jiwei Liu, Jeffrey K. Noel, and Harry H. Low, “Structural basis for membrane tethering by a bacterial dynamin-like pair,” Nature Communications, vol. 9, no. 1, 2018. View at Publisher · View at Google Scholar
  • O. I. Kiseleva, A. V. Lisitsa, and E. V. Poverennaya, “Proteoforms: Methods of Analysis and Clinical Prospects,” Molecular Biology, vol. 52, no. 3, pp. 335–349, 2018. View at Publisher · View at Google Scholar
  • Mohammed Almannai, Ayman W. El-Hattab, and Fernando Scaglia, “Mitochondrial DNA replication: clinical syndromes,” Essays In Biochemistry, pp. EBC20170101, 2018. View at Publisher · View at Google Scholar
  • Huajin Li, Evan M. Jones, Hui Li, Lizhu Yang, Zixi Sun, Zhisheng Yuan, Rui Chen, Fangtian Dong, and Ruifang Sui, “ Clinical and genetic features of eight Chinese autosomal-dominant optic atrophy pedigrees with six novel OPA1 pathogenic variants ,” Ophthalmic Genetics, pp. 1–8, 2018. View at Publisher · View at Google Scholar
  • Marcin Chodkowski, Izabela Serafińska, Joanna Brzezicka, Anna Golke, Anna Słońska, Małgorzata Krzyżowska, Piotr Orłowski, Piotr Bąska, Marcin W. Bańbura, and Joanna Cymerys, “Human herpesvirus type 1 and type 2 disrupt mitochondrial dynamics in human keratinocytes,” Archives of Virology, 2018. View at Publisher · View at Google Scholar
  • Laura Ciarlo, Matteo Marconi, Maurizio Sorice, Tina Garofalo, Paola Matarrese, Rosa Vona, Valeria Manganelli, Lucrezia Gambardella, Carla Raggi, and Walter Malorni, “Recruitment of mitofusin 2 into "lipid rafts" drives mitochondria fusion induced by Mdivi-1,” Oncotarget, vol. 9, no. 27, pp. 18869–18884, 2018. View at Publisher · View at Google Scholar
  • Michelle Williams, and M. Cecilia Caino, “Mitochondrial Dynamics in Type 2 Diabetes and Cancer,” Frontiers in Endocrinology, vol. 9, 2018. View at Publisher · View at Google Scholar
  • Daniel José Barbosa, Maria De Lourdes Bastos, João Paulo Capela, and Félix Carvalhovol. 2-2, pp. 487–508, 2018. View at Publisher · View at Google Scholar
  • Eliana Baez-Jurado, Gina Guio-Vega, Oscar Hidalgo-Lanussa, Janneth González, Valentina Echeverria, Ghulam Md Ashraf, Amirhossein Sahebkar, and George E. Barreto, “Mitochondrial Neuroglobin Is Necessary for Protection Induced by Conditioned Medium from Human Adipose-Derived Mesenchymal Stem Cells in Astrocytic Cells Subjected to Scratch and Metabolic Injury,” Molecular Neurobiology, 2018. View at Publisher · View at Google Scholar
  • Jinliang Nan, Cunjin Nan, Jian Ye, Lu Qian, Ya Geng, Dawei Xing, Muhammad Saif Ur Rahman, and Mingyuan Huang, “EGCG protects cardiomyocytes against hypoxia-reperfusion injury through inhibition of OMA1 activation,” Journal of Cell Science, vol. 132, no. 2, pp. jcs220871, 2018. View at Publisher · View at Google Scholar
  • Jing Wang, and Jean-Luc Puel, “Toward Cochlear Therapies,” Physiological Reviews, vol. 98, no. 4, pp. 2477–2522, 2018. View at Publisher · View at Google Scholar
  • Lei Kuang, Liangming Liu, and Tao Li, “The Role of Mitochondrial Quality Imbalance in Multiple Organ Dysfunction Syndrome Following Severe Trauma, Shock, and Sepsis,” Severe Trauma and Sepsis, pp. 45–65, 2019. View at Publisher · View at Google Scholar
  • Nicolas G. Brukman, Berna Uygur, Benjamin Podbilewicz, and Leonid V. Chernomordik, “How cells fuse,” The Journal of Cell Biology, pp. jcb.201901017, 2019. View at Publisher · View at Google Scholar
  • Chayodom Maneechote, Siripong Palee, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Siriporn C. Chattipakorn, and Nipon Chattipakorn, “Balancing mitochondrial dynamics via increasing mitochondrial fusion attenuates infarct size and left ventricular dysfunction in rats with cardiac ischemia/reperfusion injury,” Clinical Science, vol. 133, no. 3, pp. 497–513, 2019. View at Publisher · View at Google Scholar
  • Amy E. Vincent, Kathryn White, Tracey Davey, Jonathan Philips, R. Todd Ogden, Conor Lawess, Charlotte Warren, Matt G. Hall, Yi Shiau Ng, Gavin Falkous, Thomas Holden, David Deehan, Robert W. Taylor, Doug M. Turnbull, and Martin Picard, “Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network,” Cell Reports, vol. 26, no. 4, pp. 996–1009.e4, 2019. View at Publisher · View at Google Scholar