Review Article

[Retracted] Peripheral Cytokines as a Chemical Mediator for Postconcussion Like Sickness Behaviour in Trauma and Perioperative Patients: Literature Review

Figure 1

Release and activation of peripheral cytokines from PMBC; mechanism of cytokines transport across the blood brain barrier; IL-1, IL-6, and TNF after crossing BBB stimulate microglia to secrete endogenous cytokines as well as affect neuronal cell/transmission directly. (PMBC—peripheral mononuclear blood cells, MODS—multiorgan dysfunction syndrome, TNF—tissue necrosis factor, IL-1—interleukin 1, and IL-6—interleukin 6).
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