[Retracted] Peripheral Cytokines as a Chemical Mediator for Postconcussion Like Sickness Behaviour in Trauma and Perioperative Patients: Literature Review
Figure 1
Release and activation of peripheral cytokines from PMBC; mechanism of cytokines transport across the blood brain barrier; IL-1, IL-6, and TNF after crossing BBB stimulate microglia to secrete endogenous cytokines as well as affect neuronal cell/transmission directly. (PMBC—peripheral mononuclear blood cells, MODS—multiorgan dysfunction syndrome, TNF—tissue necrosis factor, IL-1—interleukin 1, and IL-6—interleukin 6).