Table of Contents Author Guidelines Submit a Manuscript
Neurology Research International
Volume 2014, Article ID 970793, 7 pages
http://dx.doi.org/10.1155/2014/970793
Research Article

Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement

1Department of Surgery and Cancer, Imperial College London, 10th Floor, QEQM Wing, St Mary’s Campus, London W2 1NY, UK
2Departments of Cardiac Surgery and Cardiology, Imperial College Healthcare NHS Trust, London W12 0HS, UK
3International Centre for Circulatory Health, Imperial College Healthcare NHS Trust, London W2 1LA, UK

Received 24 March 2014; Accepted 15 June 2014; Published 26 June 2014

Academic Editor: Dirk Deleu

Copyright © 2014 Emaddin Kidher et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Boutouyrie and S. J. Vermeersch, “Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: Establishing normal and reference values,” European Heart Journal, vol. 31, no. 19, pp. 2338–2350, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Laurent, P. Boutouyrie, R. Asmar et al., “Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients,” Hypertension, vol. 37, no. 5, pp. 1236–1241, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Cruickshank, L. Riste, S. G. Anderson, J. S. Wright, G. Dunn, and R. G. Gosling, “Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function?” Circulation, vol. 106, no. 16, pp. 2085–2090, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. A. R. Guérin, B. Pannier, F. Métivier, S. J. Marchais, and G. M. London, “Assessment and significance of arterial stiffness in patients with chronic kidney disease,” Current Opinion in Nephrology and Hypertension, vol. 17, no. 6, pp. 635–641, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. G. F. Mitchell, “Aortic stiffness and cerebral blood flow,” The American Journal of Hypertension, vol. 24, no. 10, article 1056, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Laurent, S. Katsahian, C. Fassot et al., “Aortic stiffness is an independent predictor of fatal stroke in essential hypertension,” Stroke, vol. 34, no. 5, pp. 1203–1206, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Okuyama, O. Hirono, H. Tamura et al., “Impact of aortic arch stiffness on recurrence of stroke in patients with acute ischemic stroke,” Circulation Journal, vol. 72, no. 8, pp. 1296–1302, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. D. A. de Silva, F. P. Woon, H. Y. Gan et al., “Arterial stiffness is associated with intracranial large artery disease among ethnic Chinese and South Asian ischemic stroke patients,” Journal of Hypertension, vol. 27, no. 7, pp. 1453–1458, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. N. Saji, K. Kimura, T. Kawarai, H. Shimizu, and Y. Kita, “Arterial stiffness and progressive neurological deficit in patients with acute deep subcortical infarction,” Stroke, vol. 43, no. 11, pp. 3088–3090, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. N. Saji, K. Kimura, H. Shimizu, and Y. Kita, “Association between silent brain infarct and arterial stiffness indicated by brachial-ankle pulse wave velocity,” Internal Medicine, vol. 51, no. 9, pp. 1003–1008, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Saji, H. Shimizu, T. Kawarai, M. Tadano, Y. Kita, and K. Yokono, “Increased brachial-ankle pulse wave velocity is independently associated with white matter hyperintensities,” Neuroepidemiology, vol. 36, no. 4, pp. 252–257, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. L. H. G. Henskens, A. A. Kroon, R. J. van Oostenbrugge et al., “Increased aortic pulse wave velocity is associated with silent cerebral small-vessel disease in hypertensive patients,” Hypertension, vol. 52, no. 6, pp. 1120–1126, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. T. Tarumi, F. Shah, H. Tanaka, and A. P. Haley, “Association between central elastic artery stiffness and cerebral perfusion in deep subcortical gray and white matter,” The American Journal of Hypertension, vol. 24, no. 10, pp. 1108–1113, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Tarumi, M. M. Gonzales, B. Fallow et al., “Central artery stiffness, neuropsychological function, and cerebral perfusion in sedentary and endurance-trained middle-aged adults,” Journal of Hypertension, vol. 31, no. 12, pp. 2400–2409, 2013. View at Google Scholar
  15. C. W. Tsao, S. Seshadri, A. S. Beiser et al., “Relations of arterial stiffness and endothelial function to brain aging in the community,” Neurology, vol. 81, no. 11, pp. 984–991, 2013. View at Publisher · View at Google Scholar
  16. C. Rosano, N. Watson, Y. Chang et al., “Aortic pulse wave velocity predicts focal white matter hyperintensities in a biracial cohort of older adults,” Hypertension, vol. 61, no. 1, pp. 160–165, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. G. C. Jickling and F. R. Sharp, “Blood biomarkers of ischemic stroke,” Neurotherapeutics, vol. 8, no. 3, pp. 349–360, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. W. Whiteley, W. L. Chong, A. Sengupta, and P. Sandercock, “Blood markers for the prognosis of ischemic stroke: a systematic review,” Stroke, vol. 40, no. 5, pp. e380–e389, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Foerch, J. Montaner, K. L. Furie, M. M. Ning, and E. H. Lo, “Invited article: searching for oracles? Blood biomarkers in acute stroke,” Neurology, vol. 73, no. 5, pp. 393–399, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. P. M. Bokesch, G. A. Izykenova, J. B. Justice, K. A. Easley, and S. A. Dambinova, “NMDA receptor antibodies predict adverse neurological outcome after cardiac surgery in high-risk patients,” Stroke, vol. 37, no. 6, pp. 1432–1436, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. M. B. Jensen, M. R. Chacon, J. A. Sattin, R. L. Levine, and R. Vemuganti, “Potential biomarkers for the diagnosis of stroke,” Expert Review of Cardiovascular Therapy, vol. 7, no. 4, pp. 389–393, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. G. J. Shaw, E. C. Jauch, and F. P. Zemlan, “Serum cleaved Tau protein levels and clinical outcome in adult patients with closed head injury,” Annals of Emergency Medicine, vol. 39, no. 3, pp. 254–257, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. B. Ramlawi, J. L. Rudolph, S. Mieno et al., “Serologic markers of brain injury and cognitive function after cardiopulmonary bypass,” Annals of Surgery, vol. 244, no. 4, pp. 593–601, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. D. C. Whitaker, A. J. E. Green, J. Stygall, M. J. G. Harrison, and S. P. Newman, “Evaluation of an alternative S100b assay for use in cardiac surgery: relationship with microemboli and neuropsychological outcome,” Perfusion, vol. 22, no. 4, pp. 267–272, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. S. A. Dambinova, G. A. Khounteev, and A. A. Skoromets, “Multiple panel of biomarkers for TIA/stroke evaluation,” Stroke, vol. 33, no. 5, pp. 1181–1182, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. S. A. Dambinova, G. A. Khounteev, G. A. Izykenova, I. G. Zavolokov, A. Y. Ilyukhina, and A. A. Skoromets, “Blood test detecting autoantibodies to N-methyl-D-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke,” Clinical Chemistry, vol. 49, no. 10, pp. 1752–1762, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. J. D. Weissman, G. A. Khunteev, R. Heath, and S. A. Dambinova, “NR2 antibodies: risk assessment of transient ischemic attack (TIA)/stroke in patients with history of isolated and multiple cerebrovascular events,” Journal of the Neurological Sciences, vol. 300, no. 1-2, pp. 97–102, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. E. I. Gusev, V. I. Skvortsova, G. A. Izykenova, A. A. Alekseev, and S. A. Dambinova, “The level of autoantibodies to glutamate receptors in the blood serum of patients in the acute period of ischemic stroke,” Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova, vol. 96, no. 5, pp. 68–72, 1996. View at Google Scholar · View at Scopus
  29. S. W. Rabkin, “Arterial stiffness: detection and consequences in cognitive impairment and dementia of the elderly,” Journal of Alzheimer's Disease, vol. 32, no. 3, pp. 541–549, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Triantafyllidi, C. Arvaniti, J. Lekakis et al., “Cognitive impairment is related to increased arterial stiffness and microvascular damage in patients with never-treated essential hypertension,” American Journal of Hypertension, vol. 22, no. 5, pp. 525–530, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Kearney-Schwartz, P. Rossignol, S. Bracard et al., “Vascular structure and function is correlated to cognitive performance and white matter hyperintensities in older hypertensive patients with subjective memory complaints,” Stroke, vol. 40, no. 4, pp. 1229–1236, 2009. View at Publisher · View at Google Scholar · View at Scopus