Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement

Table 1

Demographic and clinical characteristics and their correlation with NR2Ab level and NR2Ab 1.8 ng/mL cut-off.

Variables	Total (𝑛=56)	NR2Ab level ^a𝑟	NR2Ab 1.8 ng/mL cut-off ^a𝑟
PWV (m/s)	9.3 ± 2.2	0.28 *	0.27 *
PWV cut-off	—	0.42 **	0.43 **
NR2Ab 1.8 ng/mL cut-off	—	0.74 **	1.00
Age (years)	71 ± 8.4	−0.08	0.01
Gender (male)	40 (71.4%)	−0.26	−0.32*
DM [𝑛 (%)]	8 (14.3%)	0.14	0.09
Smoking [𝑛 (%)]	2 (3.6%)	−0.08	0.02
BMI (kg/m^2)	27.2 (4.2)	−0.21	−0.23
SBP (mmHg)	136 ± 24	−0.03	0.02
DBP (mmHg)	76 ± 11	−0.22	−0.24
PP (mmHg)	62 ± 15	0.11	0.21
MAP (mmHg)	97 ± 12	−0.11	−0.15
Cholesterol (mmol/L)	4.5 ± 1.2	0.23	0.22
Hypertension; [𝑛 (%)]	38 (67.9%)	0.18	0.14
Statin treatment [𝑛 (%)]	38 (67.9%)	0.10	0.02
PVD [𝑛 (%)]	2 (3.6%)	0.12	0.25
EuroSCORE (logistic)	5.5 ± 4.3	0.04	0.18
AVA (cm^2)	0.73 ± 0.2	−0.09	−0.10
AVMG (mmHg)	48 ± 13	0.00	−0.06
AVPG (mmHg)	82 ± 24	0.14	0.01
EF	59 ± 15	0.22	0.06

∗Correlation is significant at the 0.05 level (2-tailed); ∗∗correlation is significant at the 0.01 level (2-tailed). aCorrelation coefficient, bold values indicate statistical significance. Abbreviations: AVA, aortic valve area; AVMG, aortic valve mean gradient; AVPG, aortic valve peak gradient; BMI, body mass index; DBP, diastolic blood pressure; DM, diabetes mellitus; EF, Ejection fraction; MAP, mean arterial blood pressure; NR2Ab, N-methyl-D-aspartate (NMDA) receptor antibodies; PP, pulse pressure; PVD, peripheral vascular disease; PWV, pulse wave velocity; SBP, systolic blood pressure.