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Neurology Research International
Volume 2015, Article ID 627642, 11 pages
http://dx.doi.org/10.1155/2015/627642
Research Article

Deletion of Ovarian Hormones Induces a Sickness Behavior in Rats Comparable to the Effect of Lipopolysaccharide

1Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Isfahan (Khorasgan) Branch, Isfahan, Iran
2Neurocognitive Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Azadi Square, Mashhad 9177947564, Iran
3Neurogenic Inflammation Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
4Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
5Mashhad Technical Faculty, Technical and Vocational University, Mashhad, Iran

Received 24 September 2014; Revised 26 December 2014; Accepted 5 January 2015

Academic Editor: Changiz Geula

Copyright © 2015 Hamid Azizi-Malekabadi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Neuroimmune factors have been proposed as the contributors to the pathogenesis of sickness behaviors. The effects of female gonadal hormones on both neuroinflammation and depression have also been well considered. In the present study, the capability of deletion of ovarian hormones to induce sickness-like behaviors in rats was compared with the effect lipopolysaccharide (LPS). The groups were including Sham, OVX, Sham-LPS, and OVX-LPS. The Sham-LPS and OVX-LPS groups were treated with LPS (250 μg/kg) two hours before conducting the behavioral tests. In the forced swimming (FST), the immobility times in both OVX and Sham-LPS groups were higher than that of Sham (). In open-field (OP) test, the central crossing number by OVX and Sham-LPS groups were lower than Sham () while there were no significant differences between OVX-LPS and OVX groups. In elevated plus maze (EPM), the percent of entries to the open arm by both OVX and Sham-LPS groups was lower than that of Sham group (). The results of present study showed that deletion of ovarian hormones induced sickness behaviors in rats which were comparable to the effects of LPS. Moreover, further investigations are required in order to better understand the mechanism(s) involved.