Hypobaric Hypoxia Imbalances Mitochondrial Dynamics in Rat Brain Hippocampus

Figure 5

(a) Representative fluorescence micrograph of the temporal alterations of COX IV (mitochondrial respiratory complex IV) distribution and expression in HH exposed CA1 hippocampal region. (b) CA1 region COX IV merged with DAPI. (c) Enlarged view depicts mitochondria in neuron. Figures (i) and (ii) depict that mitochondria are equally distributed in cell soma, axons, and dendrites in Cntrl rat hippocampal tissue and figures (iii) and (iv) depict that reduction in mitochondria and distribution constraints to cell soma only in 7 dHH exposed hippocampal tissue. Yellow colour arrows indicate mitochondria as green dots of high fluorescence intensity. Data are expressed as mean ± SD; . Scale bar 10 μm, 20 μm.

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