Research Article

The Effects of Induction and Treatment of Intracranial Hypertension on Cerebral Autoregulation: An Experimental Study

Table 2

Main findings in the different steps of the experiment (SD); p<0.02 in relation to basal, p<0.02 in relation to inflation, p<0.05 for comparison with severe ICH, p=0.04 in relation to saline, #p=0.01 for differences between assessments basal and saline, λ p<0.05 for differences between other assessments between the same group, Ω p=0.04 in relation to basal. sCA (static cerebral autoregulation), ICP (intracranial pressure), CBFV (cerebral blood flow velocity), CVR (cerebral vascular resistance), MABP (mean arterial blood pressure), and ICH (intracranial hypertension).

mild ICHsevere ICH
BasalBalloon inflationSaline solutionBalloon deflationBasalBalloon inflationSaline solutionBalloon deflation

sCA index [%]78.32 (33.88)66.73 (96.23)35.85 (46.59)12.60 (30.96)74.75 (39.96)10.56 (15.05)57 (49.53)41.21 (48.36)
ICP [mmHg]4.88 (4.6)12.02 (6.64)9.88 (6.32)2.7 (2.53)8.87 (3.45)48.26 (19.05)41.23 (26.73)9.78 (5.67)
CBFV [cm/s]44.80 (22.8)41.03 (20)53.83 (27.14)48.98 (27.36)25.06 (7.55)23.21 (7.71)36.16 (21.52)29.18 (11.01)
CVR [%]28 (20)9 (34)Ω16 (35)λ-5 (21)18 (10)#-12 (21)λ20 (36)10 (42)
MABP [mmHg]77.71 (12.54)78 (17.26)80.14 (13.78)76.71 (10.06)91.62 (7.68)88.5 (12.48)89.12 (18.37)81.37 (18.81)