Serotonin Reuptake Inhibitors in Obstructive Sleep Apnea: Associations in People with and without Epilepsy
Table 5
(a) Outcomes for PWE versus PWO: +SRI compared to -SRI
Outcome
Covariate
p
OR
CI
Severe OSA compared to Moderate OSA
Unadjusted
------
0.079
0.233
0.046-1.185
Univariate
Age
0.106
0.238
0.042-1.355
Univariate
DM
0.083
0.469
0.026-5.395
Univariate
COPD/asthma
0.052
0.127
0.016-1.018
Univariate
AED
0.024
0.319
0.118-0.858
Multivariate
Age, DM, COPD/asthma, AED
0.015
0.264
0.091-0.770
Severe OSA compared to Mild OSA
Unadjusted
------
0.314
0.464
0.104-2.071
Univariate
Age
0.203
0.361
0.075-1.731
Univariate
DM
0.272
0.417
0.087-1.990
Univariate
COPD/asthma
0.266
0.412
0.087-1.964
Univariate
AED
0.447
1.471
0.545-3.970
Multivariate
Age, DM, COPD/asthma, AED
0.234
1.922
0.656-5.631
SRI: serotonin reuptake inhibitor, AED: antiepileptic drug, AHI: apnea-hypopnea index, PWO: people without epilepsy, PWE: people with epilepsy, COPD: chronic obstructive pulmonary disease, and DM: diabetes; = p<0.05. Covariate: the listed characteristic(s) designates the variable(s) adjusted for in logistic regression analysis.
(b) Outcomes for PWO: +SRI compared to -SRI
Outcome
Covariate
p
OR
CI
Severe OSA compared to moderate OSA
Unadjusted
------
0.152
0.407
0.119-1.391
Univariate
COPD/asthma
0.085
0.302
0.077-1.180
Severe OSA compared to mild OSA
Unadjusted
------
0.701
0.778
0.216-2.806
Univariate
COPD/asthma
0.579
0.687
0.182-2.591
SRI: serotonin reuptake inhibitor, PWO: people without epilepsy, and COPD: chronic obstructive pulmonary disease.
