Efficacy of High-Dose and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcomes in Patient with Acute Ischemic Stroke: A Randomized, Double-Blind, Parallel, Controlled Trial

Table 5

Compare neurological outcome in patient with acute ischemic stroke 0 days and 90 days after simvastatin therapy.

Parameter	Simvastatin 10 mg (N = 34); Mean ± SD		value	Simvastatin 40 mg (N = 31); Mean ± SD		value
	Day 0	Day 90		Day 0	Day 90
NIHSS	6.47 ± 4.90	3.15 ± 2.71	<0.001	6.61 ± 3.79	2.77 ± 3.04	<0.001
mRS	1.85 ± 1.16	1.26 ± 1.08	<0.001	1.65 ± 1.02	1.23 ± 1.18	0.002
Barthel Index	86.62 ± 12.54	90.74 ± 11.49	<0.001	87.90 ± 12.83	91.61 ± 13.25	0.004

Note. NIHSS, National Institutes of Health Stroke Scale; mRS, Modified Rankin Scale.