Table of Contents Author Guidelines Submit a Manuscript
Neurology Research International
Volume 2018, Article ID 8218697, 10 pages
https://doi.org/10.1155/2018/8218697
Research Article

The Role of Moderate Aerobic Exercise as Determined by Cardiopulmonary Exercise Testing in ALS

1Translational and Clinical Physiology Unit, Molecular Medicine Institute, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
2Department of Physical Medicine and Rehabilitation, Hospital Santa Maria-CHLN, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
3Department of Neurosciences, Hospital Santa Maria-CHLN, Lisbon, Portugal

Correspondence should be addressed to Anna Caroline Marques Braga; moc.liamtoh@oreaenilorac

Received 12 July 2017; Accepted 5 September 2017; Published 31 January 2018

Academic Editor: Laura Brighina

Copyright © 2018 Anna Caroline Marques Braga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. WHO, “World Health Organization-Physical activity Fact Sheet,” 2015.
  2. D. J. Mahoney, C. Rodriguez, M. Devries, N. Yasuda, and M. A. Tarnopolsky, “Effects of high-intensity endurance exercise training in the G93A mouse model of amyotrophic lateral sclerosis,” Muscle & Nerve, vol. 29, no. 5, pp. 656–662, 2004. View at Publisher · View at Google Scholar
  3. S. Pinto, M. Swash, and M. de Carvalho, “Respiratory exercise in amyotrophic lateral sclerosis,” Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, vol. 13, no. 1, pp. 33–43, 2012. View at Publisher · View at Google Scholar
  4. G. J. Balady, R. Arena, K. Sietsema et al., “Clinician's guide to cardiopulmonary exercise testing in adults: a scientific statement from the American heart association,” Circulation, vol. 122, no. 2, pp. 191–225, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. R. K. Binder, M. Wonisch, U. Corra et al., “Methodological approach to the first and second lactate threshold in incremental cardiopulmonary exercise testing,” European Journal of Preventive Cardiology, vol. 15, no. 6, pp. 726–734, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Majmudar, J. Wu, and S. Paganoni, “Rehabilitation in amyotrophic lateral sclerosis: Why it matters,” Muscle & Nerve, vol. 50, no. 1, pp. 4–13, 2014. View at Publisher · View at Google Scholar
  7. E. H. Cup, A. J. Pieterse, J. M. ten Broek-Pastoor et al., “Exercise therapy and other types of physical therapy for patients with neuromuscular diseases: a systematic review,” Archives of Physical Medicine and Rehabilitation, vol. 88, no. 11, pp. 1452–1464, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. M. F. Beal, “Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?” Annals of Neurology, vol. 31, no. 2, pp. 119–130, 1992. View at Google Scholar
  9. Supplementary Guidance for authors undertaking reviews with the Cochrane Consumers and communication review Group, http://cccrg.cochrane.org/author-resources.
  10. R. G. Miller, C. E. Jackson, E. J. Kasarskis, and et al., “Practice parameters update:the care of the patient with a myotrophic lateral sclerosis:drug, nutritional and respiratory the rapies (anevidence-basedreview),” Neurology, vol. 73, 2009. View at Google Scholar
  11. A. Pinto, T. Evangelista, M. Carvalho, M. Alves, and M. Sales Luís, “Respiratory assistance with a non-invasive ventilator (Bipap) in MND/ALS patients: Survival rates in a controlled trial,” Journal of the Neurological Sciences, vol. 129, pp. 19–26, 1995. View at Publisher · View at Google Scholar
  12. S. Bourke, M. Tomlinson, T. Williams, R. Bullock, P. Shaw, and G. Gibson, “Effects of Non-invasive ventilation on survival and quality of life in pationts with amyotrophic lateral sclerosis: a randomised controlled trial,” Lancet Neurol, vol. 5, no. 2, pp. 140–147, 2006. View at Publisher · View at Google Scholar
  13. A. Chetta, M. Aiello, and P. Tzani, “Assessment and monitoring of ventilator function and cough efficacy in patients with amyotrophic lateral sclerosis,” Monaldi Archives for Chest Diseases, vol. 67, no. 1, pp. 43–52, 2007. View at Google Scholar
  14. Excellence NIfHaC, “The use of non-invasive ventilation in the management of motor neurone disease,” NICE Clinical Guideline 105, 2010, London, UK. View at Google Scholar
  15. J. M. Cedarbaum, N. Stambler, E. Malta et al., “The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function,” Journal of the Neurological Sciences, vol. 169, no. 1-2, pp. 13–21, 1999. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Pinto, M. de Carvalho, T. Evangelista, A. Lopes, and L. Sales-Luís, “Nocturnal pulse oximetry: a new approach to establish the appropriate time for non-invasive ventilation in ALS patients,” Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, vol. 4, no. 1, pp. 31–35, 2003. View at Publisher · View at Google Scholar
  17. P. M. Andersen, S. Abrahams, G. D. Borasio et al., “EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (mals)—revised report of an efns task force,” European Journal of Neurology, vol. 19, 2012. View at Google Scholar
  18. K. Wasserman, J. E. Hansen, D. Y. Sue et al., Principles of Exercise Testing and Interpretation: Including Pathophysiology and Clinical Applications, Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia, PA, USA, 5th edition, 2012.
  19. American Thoracic Society/European Respiratory Society, “ATS/ERS Statement on respiratory muscle testing,” American Journal of Respiratory and Critical Care Medicine, vol. 166, no. 4, pp. 518–624, 2002. View at Google Scholar
  20. S. Vucic, A. V. Krishnan, and M. C. Kiernan, “Fatigue and activity dependent changes in axonal excitability in amyotrophic lateral sclerosis,” Journal of Neurology, Neurosurgery & Psychiatry, vol. 78, no. 11, pp. 1202–1208, 2007. View at Publisher · View at Google Scholar
  21. V. Dalbello-Haas, J. M. Florence, and L. S. Krivickas, “Therapeutic exercise for people with amyotrophic lateral sclerosis or motor neuron disease,” The Cochrane Database of Systematic Reviews 2, 2008. View at Google Scholar
  22. W. Longstreth, L. Nelson, T. Koepsell, and G. Van Belle, “Hypotheses to explain the association between vigorous physical activity and amyotrophic lateral sclerosis,” Medical Hypotheses, vol. 34, no. 2, pp. 144–148, 1991. View at Publisher · View at Google Scholar
  23. A. Anand, K. Thakur, and P. K. Gupta, “ALS and oxidative stress: the neurovascular scenario,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 635831, 14 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Sanjak, D. Paulson, R. Sufit et al., “Physiologic and metabolic response to progressive and prolonged exercise in amyotrophic lateral sclerosis,” Neurology, vol. 37, no. 7, pp. 1217–1220, 1987. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Mezzani, F. Pisano, A. Cavalli et al., “Reduced exercise capacity in early-stage amyotrophic lateral sclerosis: Role of skeletal muscle,” Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, vol. 13, no. 1, pp. 87–94, 2012. View at Publisher · View at Google Scholar
  26. G. Siciliano, C. D'Avino, A. D. Corona et al., “Impaired oxidative metabolism and lipid peroxidation in exercising muscle from ALS patients,” Amyotrophic Lateral Scler Other Motor Neuron Disord, vol. 3, no. 2, pp. 57–62, 2002. View at Publisher · View at Google Scholar
  27. R. A. Battista, C. Foster, J. Andrew, G. Wright, A. Lucia, and J. P. Porcari, “Physiologic responses during indoor cycling,” The Journal of Strength and Conditioning Research, vol. 22, no. 4, pp. 1236–1241, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. D. W. Hill and A. L. Rowell, “Significance of time to exhaustion during exercise at the velocity associated with VO2max,” European Journal of Applied Physiology, vol. 72, no. 4, pp. 383–386, 1996. View at Google Scholar
  29. C. Lunetta, A. Lizio, V. A. Sansone et al., “Strictly monitored exercise programs reduce motor deterioration in ALS: preliminary results of a randomized controlled trial,” Journal of Neurology, vol. 263, no. 1, pp. 52–60, 2016. View at Publisher · View at Google Scholar · View at Scopus
  30. T. van Wessel, A. de Haan, W. J. van der Laarse, and R. T. Jaspers, “The muscle fiber type-fiber size paradox: hypertrophy or oxidative metabolism?” European Journal of Applied Physiology, vol. 110, no. 4, pp. 665–694, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. F. Lanfranconi, A. Ferri, G. Corna et al., “Inefficient skeletal muscle oxidative function flanks impaired motor neuron recruitment in Amyotrophic Lateral Sclerosis during exercise,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  32. S. Paganoni, M. Cudkowicz, and J. Berry, “Outcome measures in amyotrophic lateral sclerosis clinical trials,” Clinical Investigation, vol. 4, no. 7, pp. 605–618, 2014. View at Publisher · View at Google Scholar
  33. V. Dal Bello-Haas and J. M. Florence, “Therapeutic exercise for people with amyotrophic lateral sclerosis or motor neuron disease,” Cochrane Database Systematic Reviews 5, 2013. View at Google Scholar
  34. C. A. Blizzard, K. A. Southam, E. Dawkins et al., “Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis - vulnerability of lower motor neurons to proximal excitotoxicity,” Disease Models & Mechanisms, vol. 8, no. 3, pp. 215–224, 2015. View at Publisher · View at Google Scholar
  35. R. Carilho, M. de Carvalho, M. Swash, S. Pinto, A. Pinto, and J. Costa, “Vascular endothelial growth factor and amyotrophic lateral sclerosis: the interplay with exercise and noninvasive ventilation,” Muscle & Nerve, vol. 49, no. 4, pp. 545–550, 2014. View at Publisher · View at Google Scholar · View at Scopus
  36. T. Takken, W. G. Groen, E. H. Hulzebos et al., “Exercise stress testing in children with metabolic or neuromuscular disorders,” International Journal of Pediatrics, vol. 2010, pp. 1–6, 2010. View at Publisher · View at Google Scholar