Effect of Different Doses and Times of FK506 on Different Areas of the Hippocampus in the Rat Model of Transient Global Cerebral Ischemia-Reperfusion

<p>TUNEL staining of rats’ hippocampal dentate gyrus area. There were high apoptotic bodies (TUNEL-positive cell) in I/R group in comparison with control group (TUNEL-negative). Also, treated rats with different dose of FK506 at different time showed decreased TUNEL-positive cells (red arrows) in comparison with I/R group. However, this change was not statistically significant in E1, indicating that a repeated dose was needed for the protective effects of FK506 against ischemia (400× magnification, scale bar= 50  <i>μ</i>m).</p>

Neurology Research International

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Figure 3

Figure 3: Effect of Different Doses and Times of FK506 on Different Areas of the Hippocampus in the Rat Model of Transient Global Cerebral Ischemia-Reperfusion 

Figure 3 | Effect of Different Doses and Times of FK506 on Different Areas of the Hippocampus in the Rat Model of Transient Global Cerebral Ischemia-Reperfusion 