HMGB1 is a Potential Mediator of Astrocytic TLR4 Signaling Activation following Acute and Chronic Focal Cerebral Ischemia

<div>TLR4 expression is increased in penumbral astrocytes during chronic focal cerebral ischemia, 7 days post 3 h MCAO (<i>n</i> = 3). Brain sections immunolabeled for GFAP (green) and TLR4 (red), in penumbral astrocytes (merged), in the ipsilateral ischemic hemisphere (upper). Brain sections immunolabeled for GFAP (green) and TLR4 (red) in cortical astrocytes (merged) in the contralateral hemisphere (lower panel). Scale bar = 50 <i>μ</i>m.</div>

Neurology Research International

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Figure 3

Figure 3: HMGB1 is a Potential Mediator of Astrocytic TLR4 Signaling Activation following Acute and Chronic Focal Cerebral Ischemia 