Evaluation of Retinal Structure and Optic Nerve Function Changes in Multiple Sclerosis: Longitudinal Study with 1-Year Follow-Up

Table 2

Comparison of BCVA, contrast sensitivity, GCIPL, RNFL, P100 latency, and fundus image between MS and healthy controls (HCs).

Variable	n	MS	n	HC	value
Median (range)
BCVA (logmar)	58	0.00 (0.00–1.77)	44	0.00 (0.00–0.10)	0.001^b
Contrast sensitivity	53	1.65 (0.90–1.95)	44	1.95 (1.65–1.95)	0.00000000028^b
Mean ± standard deviation
GCIPL
Mean	54	70.89 ± 10.60	43	84.72 ± 2.99	0.00000000000036^a
Superior	54	71.11 ± 11.44	43	86.05 ± 2.96	0.000000000083^b
Superonasal	54	71.00 ± 12.51	43	87.58 ± 3.56	0.000000000033^b
Inferonasal	54	70.28 ± 12.74	43	85.53 ± 3.99	0.0000000027^b
Inferior	54	69.35 ± 11.06	43	82.30 ± 4.07	0.000000000022^a
Inferotemporal	54	71.83 ± 10.12	43	83.72 ± 3.74	0.0000000021^b
Superotemporal	54	71.15 ± 9.82	43	83.53 ± 4.00	0.00000000006^b
RNFL
Mean	54	88.48 ± 14.08	44	102.50 ± 7.76	0.000000016^a
Superior	54	115.69 ± 21.95	44	132.36 ± 12.34	0.000008^a
Nasal	54	68.17 ± 10.60	44	71.73 ± 11.58	0.12^a
Inferior	54	110.28 ± 20.78	44	134.93 ± 15.14	0.00000000099^a
Temporal	54	59.37 ± 16.82	44	70.80 ± 7.90	0.00003^a
P100 latency	54	116.63 ± 19.19	220	100.62 ± 5.73	0.0000000098^b
Fundus image; N (%)
Normal	31 (57.4)		44 (100)		0.00000075^c
Optic atrophy	23 (42.6)		0 (0,0)

BCVA: best-corrected visual acuity; GCIPL: ganglion cell inner plexiform layer; RNFL: retinal nerve fiber layer. ^aT-independent test, ^bMann–Whitney test, ^cChi-square test.