The Role of ACE2 Receptors of the Olfactory System in Anosmia in COVID-19: An Overview

Figure 1

The probable mechanism of SARS-CoV-2 entry into the nasal cavity. TMPRSS2 and ACE2 are receptors existing on the surface of olfactory nonneural epithelium cells. TMPRRS2 activates the spike protein by cleaving viral S-glycoprotein. After that, the virus binds to the ACE2 receptor, and through this way, it can gain entry into human cells.