|
| Site | Guide | FUS application | Target | Ongoing clinical trials | Published results | Stage |
|
| CNS | MR | Chronic neuropathic pain | Thalamus (CL nucleus) | NCT03111277 | [51,52] | Human ¶ |
| MR | Chronic pain from spinal cord injury |
| MR | Phantom limb pain |
| MR | Chronic trigeminal neuropathic pain | Medial thalamus | NCT03309813 | | |
| NA | Chronic neuropathic pain | Spinal commissurotomy | — | [53] | Preclinical (not further developed) |
|
| PNS | Management of tumor-related pain |
| MR or US | (1) Bone metastases and primary bone malignancies related pain | Lesion | NCT02616016
NCT02718404
NCT01833806
NCT03106675
NCT00981578
NCT01091883
NCT02076906 | [54–67] | Human ¶, § |
| MR or US | (1) Osteoid osteoma and other benign bone tumors related pain | Lesion | NCT02618369
NCT02923011 | [68–75] | Human ¶ |
| MR or US | (1) Uterine fibroids related pain | Lesion | NCT02736435 | [76–93] | Human ¶, § |
| MR or US | (1) Breast fibroadenoma related pain | Lesion | NCT02488655
NCT03044054 | — | Human ¶ |
| MR or US | (1) Pancreatic cancer-related pain palliative treatment | Lesion | NCT01786850 (expanded acc.)
NCT00637364 (suspended) | [94–114] | Human ¶ |
| NA | (1) Recurrent rectal cancer-related pain palliative treatment | Lesion | NCT02528175 | — | Human |
| NA | (1) Recurrent gynecological cancer-related pain palliative treatment | Lesion | NCT02714621 | [78] | Human (case report) |
| NA | (1) Advanced rectal and gynecological cancers-related pain palliative treatment | Lesion | NCT01097239 | — | — |
| Other nontumoral gynecologic conditions |
| US | (1) Endometriosis related pain | Lesion | — | [103, 115–117] | Human |
| US | (1) Adenomyosis related pain | Lesion | — | [118] | Human |
| Management of bone/joint nontumoral pain |
| MR | (1) Low back pain from lumbar facet joint osteoarthritis (without radiculopathy) | Facet joint/lumbar medial branch nerve | NCT03321344 | [119, 120] | (a) Human ¶
(b) Preclinical |
| MR | (1) Low back pain from lumbar sacroiliac joint dysfunction | Sacroiliac joint | — | [121] | Preclinical |
| NA | (1) Spinal disc herniation related pain | Intervertebral disc | — | [122, 123] | Preclinical (not further developed) |
| MR | (1) Knee osteoarthritis related chronic pain | Knee joint | — | [124] | Human |
| Other |
| MR | Phantom/residual limb pain | Stump neuromas | NCT03255395 | — | Human |
| MR or US | Chronic neuropathic pain (nerve ablation, irreversible conduction block) | Peripheral nerves | — | [120, 125–128] | Preclinical |
|
