Brain Connectivity and Network Analysis in Amyotrophic Lateral Sclerosis

Figure 5

Averaged 2D connectograms and 3D structural networks of controls and patients (created with CIRCOS [78] and DSI studio [79])] showing reduced structural network connectivity in ALS. Both 2D and 3D models depict a reduced density of white matter connections in ALS patients (R) compared to controls (L). The patterns of connectivity changes can also be visualized.