Table of Contents Author Guidelines Submit a Manuscript
Nursing Research and Practice
Volume 2010, Article ID 281531, 9 pages
http://dx.doi.org/10.1155/2010/281531
Research Article

Increased Interleukin-6 Activity Associated with Painful Chemotherapy-Induced Peripheral Neuropathy in Women after Breast Cancer Treatment

School of Nursing, Virginia Commonwealth University, Richmond, VA 23298-0567, USA

Received 26 December 2009; Revised 18 May 2010; Accepted 7 July 2010

Academic Editor: Patsy Yates

Copyright © 2010 Angela Starkweather. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Armstrong, L. Almadrones, and M. R. Gilbert, “Chemotherapy-induced peripheral neuropathy,” Oncology Nursing Forum, vol. 32, no. 2, pp. 305–311, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. J. A. Paice, “Clinical challenges: chemotherapy-induced peripheral neuropathy,” Seminars in Oncology Nursing, vol. 25, no. 2, pp. S8–S19, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. R. C. Polomano and J. T. Farrar, “Pain and neuropathy in cancer survivors,” American Journal of Nursing, vol. 106, no. 3, pp. 39–47, 2006. View at Google Scholar · View at Scopus
  4. C. Visovsky and B. J. Daly, “Clinical evaluation and patterns of chemotherapy-induced peripheral neuropathy,” Journal of the American Academy of Nurse Practitioners, vol. 16, no. 8, pp. 353–359, 2004. View at Google Scholar · View at Scopus
  5. A. Bhagra and R. D. Rao, “Chemotheraphy-induced neuropathy,” Current Oncology Reports, vol. 9, no. 4, pp. 290–299, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. C. C. P. Verstappen, J. J. Heimans, K. Hoekman, and T. J. Postma, “Neurotoxic complications of chemotherapy in patients with cancer,” Drugs, vol. 63, no. 15, pp. 1549–1563, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Wolf, D. Barton, L. Kottschade, A. Grothey, and C. Loprinzi, “Chemotherapy-induced peripheral neuropathy: prevention and treatment strategies,” European Journal of Cancer, vol. 44, no. 11, pp. 1507–1515, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. B. Malik and M. Stillman, “Chemotherapy-induced peripheral neuropathy,” Current Neurology and Neuroscience Reports, vol. 8, no. 1, pp. 56–65, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Wickham, “Chemotherapy-induced peripheral neuropathy: a review and implications for oncology nursing practice,” Clinical Journal of Oncology Nursing, vol. 11, no. 3, pp. 361–376, 2007. View at Google Scholar · View at Scopus
  10. C. S. Cleeland, G. J. Bennett, R. Dantzer et al., “Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism?” Cancer, vol. 97, no. 11, pp. 2919–2925, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Scheller, N. Ohnesorge, and S. Rose-John, “Interleukin-6 trans-signalling in chronic inflammation and cancer,” Scandinavian Journal of Immunology, vol. 63, no. 5, pp. 321–329, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. N. Üçeyler, J. P. Rogausch, K. V. Toyka, and C. Sommer, “Differential expression of cytokines in painful and nonpainful neuropathies,” Neurology, vol. 69, no. 1, pp. 42–49, 2008. View at Google Scholar
  13. P. W. Mantyh, “Cancer pain and its impact on diagnosis, survival and quality of life,” Nature Reviews Neuroscience, vol. 7, no. 10, pp. 797–809, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. O. Caffo, M. Amichetti, A. Ferro, A. Lucenti, F. Valduga, and E. Galligioni, “Pain and quality of life after surgery for breast cancer,” Breast Cancer Research and Treatment, vol. 80, no. 1, pp. 39–48, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Montazeri, M. Vahdaninia, I. Harirchi, M. Ebrahimi, F. Khaleghi, and S. Jarvandi, “Quality of life in patients with breast cancer before and after diagnosis: an eighteen months follow-up study,” BMC Cancer, vol. 8, pp. 330–336, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. J. B. Schnur, M. N. Hallquist, D. H. Bovbjerg, J. H. Silverstein, A. Stojceska, and G. H. Montgomery, “Predictors of expectancies for post-surgical pain and fatigue in breast cancer surgical patients,” Personality and Individual Differences, vol. 42, no. 3, pp. 419–429, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. L. R. Watkins, M. R. Hutchinson, E. D. Milligan, and S. F. Maier, ““Listening” and “talking” to neurons: implications of immune activation for pain control and increasing the efficacy of opioids,” Brain Research Reviews, vol. 56, no. 1, pp. 148–169, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Okamoto, D. P. Martin, J. D. Schmelzer, Y. Mitsui, and P. A. Low, “Pro- and anti-inflammatory cytokine gene expression in rat sciatic nerve chronic constriction injury model of neuropathic pain,” Experimental Neurology, vol. 169, no. 2, pp. 386–391, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. W. Guo, H. Wang, M. Watanabe et al., “Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain,” Journal of Neuroscience, vol. 27, no. 22, pp. 6006–6018, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Sommer, T. Lindenlaub, P. Teuteberg, M. Schäfers, T. Hartung, and K. V. Toyka, “Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy,” Brain Research, vol. 913, no. 1, pp. 86–89, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. J.-M. Zhang and J. An, “Cytokines, inflammation, and pain,” International Anesthesiology Clinics, vol. 45, no. 2, pp. 27–37, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. R. F. De Jongh, K. C. Vissers, T. F. Meert, L. H. D. J. Booij, C. S. De Deyne, and R. J. Heylen, “The role of interleukin-6 in nociception and pain,” Anesthesia & Analgesia, vol. 96, no. 4, pp. 1096–1103, 2003. View at Google Scholar · View at Scopus
  23. H.-L. Lee, K.-M. Lee, S.-J. Son, S.-H. Hwang, and H.-J. Cho, “Temporal expression of cytokines and their receptors mRNAs in a neuropathic pain model,” Neuroreport, vol. 15, no. 18, pp. 2807–2811, 2004. View at Google Scholar · View at Scopus
  24. O. Obreja, M. Schmelz, S. Poole, and M. Kress, “Interleukin-6 in combination with its soluble IL-6 receptor sensitises rat skin nociceptors to heat, in vivo,” Pain, vol. 96, no. 1-2, pp. 57–62, 2002. View at Publisher · View at Google Scholar · View at Scopus
  25. G. Kaplanski, V. Marin, F. Montero-Julian, A. Mantovani, and C. Farnarier, “IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation,” Trends in Immunology, vol. 24, no. 1, pp. 25–29, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. P. C. Heinrich, I. Behrmann, S. Haan, H. M. Hermanns, G. Müller-Newen, and F. Schaper, “Principles of interleukin (IL)-6-type cytokine signalling and its regulation,” Biochemical Journal, vol. 374, no. 1, pp. 1–20, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. R. M. McLoughlin, J. Witowski, R. L. Robson et al., “Interplay between IFN-γ and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation,” Journal of Clinical Investigation, vol. 112, no. 4, pp. 598–607, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Ernst and B. J. Jenkins, “Acquiring signalling specificity from the cytokine receptor gp130,” Trends in Genetics, vol. 20, no. 1, pp. 23–32, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. C. C. Reyes-Gibby, P. K. Morrow, A. Buzdar, and S. Shete, “Chemotherapy-induced peripheral neuropathy as a predictor of neuropathic pain in breast cancer patients previously treated with paclitaxel,” Journal of Pain, vol. 10, no. 11, pp. 1146–1150, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Melzack, “The McGill pain questionnaire,” in Pain Measurement and Assessment, R. Melzack, Ed., pp. 41–47, Raven Press, New York, NY, USA, 1983. View at Google Scholar
  31. J. E. Ware, M. Kosinski, and J. E. Dewey, How to Score Version 2 of the SF-36 Health Survey, Medical Outcomes Trust and QualityMetric Incorporated, Lincoln, RI, USA, 2002.
  32. S. A. Jones, “Directing transition from innate to acquired immunity: defining a role for IL-6,” Journal of Immunology, vol. 175, no. 6, pp. 3463–3468, 2005. View at Google Scholar · View at Scopus
  33. A. Collado-Hidalgo, J. E. Bower, P. A. Ganz, S. W. Cole, and M. R. Irwin, “Inflammatory biomarkers for persistent fatigue in breast cancer survivors,” Clinical Cancer Research, vol. 12, no. 9, pp. 2759–2766, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Andratsch, N. Mair, C. E. Constantin et al., “A key role for gp130 expressed on peripheral sensory nerves in pathological pain,” Journal of Neuroscience, vol. 29, no. 43, pp. 13473–13483, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. W. Ma and R. Quirion, “Up-regulation of interleukin-6 induced by prostaglandin E2 from invading macrophages following nerve injury: an in vivo and in vitro study,” Journal of Neurochemistry, vol. 93, no. 3, pp. 664–673, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. N. Kiguchi, T. Maeda, Y. Kobayashi, T. Kondo, M. Ozaki, and S. Kishioka, “The critical role of invading peripheral macrophage-derived interleukin-6 in vincristine-induced mechanical allodynia in mice,” European Journal of Pharmacology, vol. 592, no. 1–3, pp. 87–92, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. C. M. Peters, J. M. Jimenez-Andrade, B. M. Jonas et al., “Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells,” Experimental Neurology, vol. 203, no. 1, pp. 42–54, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. K. Nishida, S. Kuchiiwa, S. Oiso et al., “Up-regulation of matrix metalloproteinase-3 in the dorsal root ganglion of rats with paclitaxel-induced neuropathy,” Cancer Science, vol. 99, no. 8, pp. 1618–1625, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. C. L. Loprinzi, K. Maddocks-Christianson, S. L. Wolf et al., “The paclitaxel acute pain syndrome: sensitization of nociceptors as the putative mechanism,” The Cancer Journal, vol. 13, no. 6, pp. 399–403, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. K. Meyer-Rosberg, A. Kvarnström, E. Kinnman, T. Gordh, L.-O. Nordfors, and A. Kristofferson, “Peripheral neuropathic pain—a multidimensional burden for patients,” European Journal of Pain, vol. 5, no. 4, pp. 379–389, 2001. View at Publisher · View at Google Scholar · View at Scopus
  41. B. H. Smith, N. Torrance, M. I. Bennett, and A. J. Lee, “Health and quality of life associated with chronic pain of predominantly neuropathic origin in the community,” Clinical Journal of Pain, vol. 23, no. 2, pp. 143–149, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. M. Hashizume and M. Mihara, “Influence of humanized anti-IL-6R antibody, tocilizumab on the activity of soluble gp130, natural inhibitor of IL-6 signaling,” Rheumatology International, vol. 29, no. 4, pp. 397–401, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. J. S. Smolen, A. Beaulieu, A. Rubbert-Roth et al., “Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial,” The Lancet, vol. 371, no. 9617, pp. 987–997, 2008. View at Publisher · View at Google Scholar · View at Scopus
  44. Z. Nurgalieva, R. Xia, C.-C. Liu, K. Burau, D. Hardy, and X. L. Du, “Risk of chemotherapy-induced peripheral neuropathy in large population-based cohorts of elderly patients with breast, ovarian, and lung cancer,” American Journal of Therapeutics, vol. 17, no. 2, pp. 148–158, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. K. Kuroi, K. Shimozuma, Y. Ohashi et al., “Prospective assessment of chemotherapy-induced peripheral neuropathy due to weekly paclitaxel in patients with advanced or metastatic breast cancer (CSP-HOR 02 study),” Supportive Care in Cancer, vol. 17, no. 8, pp. 1071–1080, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. K. Shimozuma, Y. Ohashi, A. Takeuchi et al., “Feasibility and validity of the Patient Neurotoxicity Questionnaire during taxane chemotherapy in a phase III randomized trial in patients with breast cancer (N-SAS BC 02 study),” Supportive Care in Cancer, vol. 17, no. 12, pp. 1483–1490, 2009. View at Publisher · View at Google Scholar · View at Scopus