Research Article

Development and Evaluation of Evidence-Informed Clinical Nursing Protocols for Remote Assessment, Triage and Support of Cancer Treatment-Induced Symptoms

Table 4

Characteristics of guidelines about febrile neutropenia ( ).

Author (year)CountryDefines symptomCriteria to assess symptomRisk stratificationSelf-care to manage symptomFollowup for ongoing monitoringOther recommendations in guidelineRigour score
(raters would recommend)

Hughes et al. (2002) [41]USA ≥38.3°C or ≥38°C for 1 hour and <500 cell/mm3 or <1000 cell/mm3 and expected to dropSee scoring index on Table 4 of Hughes et al. (2002) [41]Scoring index on Table 4 of the paper for MASCC risk indexUse of prescribed medications62 (4/4)
NCCN (2008) [40]USARefers to Hughes
et al. [41]
Temperature, neutrophil countMASCC risk indexUse of prescribed medications48 (2/4)
Mendes et al. (2007) [43]BrazilRefers to Hughes
et al. [41]
Temperature, neutrophil count, sepsesInfectious diseases working group, German Society of Haematology and OncologyReassess in 12 to 24 hours if neutropenia onlyUse of prescribed medications33 (4/4)
Cancer Care Ontario (2004) [37]Canada≥38°CMany items (temperature, chills, other symptoms, etc.)Nonurgent, urgent, emergentMonitor temperature; minimize infection riskTake temperature every 2–4 hours23 (2/4)
Gaillet (2007) [42]FranceExcluded due to low quality score; no data extracted14 (0/4)

—: none; NCCN: National Comprehensive Cancer Network; MASCC: Multinational Association for Supportive Care in Cancer.