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Nursing Research and Practice
Volume 2013, Article ID 687519, 9 pages
http://dx.doi.org/10.1155/2013/687519
Research Article

Epigenetic Markers of Renal Function in African Americans

1Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
2Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, No. 4629, Ann Arbor, MI 48109, USA
3Center for Health Statistics, Washington State Department of Health, Olympia, WA 98501, USA
4School of Nursing, Yale University, New Haven, CT 06477, USA
5Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA

Received 1 September 2013; Accepted 27 October 2013

Academic Editor: Ida J. Spruill

Copyright © 2013 Samantha M. Bomotti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The supplementary material includes five tables and two figures that further characterize the relationship between DNA methylation markers, traditional risk factors for kidney function, and estimated glomerular filtration rate (eGFR). Specifically, the tables show the correlation between the 30 methylation sites most strongly associated with eGFR (Supplementary Table 1), the relationship between these 30 methylation sites and the four risk factors that are most strongly associated with eGFR (Supplementary Table 2), the variation in eGFR that is explained by each of the 30 methylation sites after adjusting for each risk factor individually (Supplementary Table 3), the variation in eGFR that is explained by each of the 30 methylation sites after adjusting for all significant risk factors (Supplementary Table 4), and the variation in eGFR that is explained by the final model that includes the significant risk factors and methylation sites (Supplementary Table 5). Supplementary Figure 1 shows the distribution of the M-value for the 26,428 DNA methylation sites that were tested for association with eGFR. Supplementary Figure 2 shows the quantile-quantile plot of the association between each of the 26,428 DNA methylation sites and eGFR, without adjustment for any risk factors.

  1. Supplementary Material