Figure 1: Increased frequency of micronuclei (MN) in women with FM. (a) A representative cell blocked at the cytokinesis phase of mitosis is shown. Karyokinesis has been completed, resulting in 2 daughter binucleates having a single MN (arrow). (b) The frequency of MN ( -axis) showed the expected age-related increase (age on -axis) for both controls (Spearman’s rho = 0.579) and patients having FM (Spearman’s rho = 0.717). The least squares regression line with corresponding 95% confidence interval (grey region) is shown for each group. After controlling for age effects, the frequencies of MN were found to be significantly higher in the women with FM compared to healthy controls ( ).