|
| Gene name (abbreviation) | Description of function1 | Location2 |
|
AXL receptor tyrosine kinase (AXL)
| Involved in stimulation of cell proliferation and aggregation; induced by TGF-β1/inflammation; and can block cytokine production | 19: 41731934 |
| N-Acetyltransferase 15 (NAT15) | Histone acetyltransferase; mediates acetylation of free histone H4; also required for normal chromosomal segregation during anaphase | 16: 3507460 |
| Solute carrier family 17, member 9 (SLC17A9) | Vesicular nucleotide transporter involved in exocytosis of ATP in secretory vesicles (synaptic vesicles) | 20: 61584072 |
| Brain-derived neurotrophic factor (BDNF) | Involved in the regulation of stress response and in the biology of mood disorders; major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS; contributes to several adaptive neuronal responses including long-term potentiation, long-term depression, certain forms of short-term synaptic plasticity, and homeostatic regulation of intrinsic neuronal excitability | 11: 27740495 |
| Mahogunin ring finger 1, E3 ubiquitin protein ligase (MGRN1) | Mediates monoubiquitination at multiple sites; plays a role in the regulation of endosome-to-lysosome trafficking. | 16: 4714733 |
| Plasma glutamate carboxypeptidase (PGCP) | Involved in hydrolysis of circulating peptides | 8: 97657294 |
| Protein kinase C, alpha (PRKCA) | Involved in diverse cell signaling pathways; activated by calcium; associated with cancer; posttraumatic stress syndrome; emotional memory formation; and aging | 17: 64787379 |
| Gamma-glutamyltransferase 1 (GGT1) | Function not clear and may vary; has been associated with arterial stiffness and coronary artery disease [47] | 22: 24989248 |
| Reticulon 1 (RTN1) | Involved in secretion or membrane trafficking in neuroendocrine cells; associated with neurological diseases and cancer | 14: 60097209 |
| NFXL1 nuclear transcription factor, X-box binding-like 1 (NFXL1) | Integral to the nucleus and membrane | 4: 47917042 |
| Heat shock 70 kDa protein 8 (HSPA8) | Member of the heat shock protein family, functions as a chaperone and facilitates protein folding | 11: 122933028 |
| Polymeric immunoglobulin receptor (PIGR) | Member of the immunoglobulin superfamily that facilitates expression of immunoglobulins A and M; regulated by cytokines | 1: 207103660 |
| Benzodiazepine receptor (peripheral) associated protein 1 (BZRAP1) | An adaptor molecule known to regulate synaptic transmission [48] | 17: 56401800 |
| Transmembrane protein 91 (TMEM91) | In vivo function not clearly established | 19: 41882253 |
| Neuron-derived orphan receptor 1 (NR4A3) | Target of β-andrenergic signaling in skeletal muscle [49] | 9: 102588232 |
| V-set and immunoglobulin domain containing 10 (VSIG10) | In vivo function not clearly established | 12: 118541722 |
| Potassium voltage-gated channel subfamily H member 7 (KCNH7) | Involved in regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. | 2: 163695111 |
| V-set and transmembrane domain containing 2A (VSTM2A) | In vivo function not clearly established | 7: 54609587 |
| Ephrin type-A receptor 2 (EPHA2) | Protein-tyrosine kinase family member; implicated in mediating developmental events, particularly in the nervous system. | 1: 16482553 |
| Patched 2 (PTCH2) | A transmembrane receptor of the patched gene family; may function as a tumor suppressor in the hedgehog signaling pathway; has been associated with several different types of cancer | 1: 45297445 |
| Histone deacetylase 4, (HDAC4) | Responsible for the deacetylation of the core histones; gives tag for epigenetic repression; plays important role in transcriptional regulation, cell cycle progression, and developmental events; also involved in muscle maturation through interaction with the myocyte enhancer factors | 2: 240044021 |
| ADP-ribosylarginine hydrolase (ADPRH) | Catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. | 3: 119299162 |
| Fasciculation and elongation protein zeta 1 (zygin I) (FEZ1) | Involved in normal axonal bundling and elongation within axon bundles; may also function in axonal outgrowth. | 11: 125365478 |
| Superoxide dismutase 3, extracellular (SOD3) | Antioxidant enzyme thought to protect the brain, lungs, and other tissues from oxidative stress. | 4: 24801801 |
| Transcription factor AP-2 alpha 2 (TFAP2A) | Transcription factor; activates the transcription of some genes while inhibiting the transcription of others | 6: 10420079 |
| Odz, odd Oz/ten-m homolog 3 (ODZ3) | May function as a cellular signal transducer | 4: 183370512 |
| Ephrin type A receptor 5 (EPHA5) | Mediates developmental events, particularly in the nervous system; plays a role in synaptic plasticity in adult brain through regulation of synaptogenesis; also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion | 4: 66535145 |
| Suppressor of fused homolog (Drosophila) (SUFU) | Plays a role in pattern formation and cellular proliferation during development; encodes a negative regulator of the hedgehog signaling pathway | 10: 104393081 |
| Rh family, C glycoprotein (RHCG) | Functions as an electroneutral and bidirectional ammonium transporter | 15: 90039613 |
| DNAJ (Hsp40) homolog, subfamily C, member 17 (DNAJC17) | Heat shock protein homolog | 15: 41062113 |
| Autism susceptibility candidate 2 (AUTS2) | Function not fully known; deletions of this gene have been associated with autism and intellectual disability | 7: 70158761 |
| Deleted in lymphocytic leukemia, 7 (DLEU7) | In vivo function not clearly established | 13: 51417846 |
| SH2B adaptor protein 2 (SH2B2) | Involved in multiple signaling pathways; may function as a negative regulator of cytokine signaling; suppresses PDGF-induced mitogenesis: may induce cytoskeletal reorganization via interaction with VAV3 | 7: 101934892 |
| Alpha-kinase 3 (ALPK3) | Recognizes phosphorylation sites (alpha-helical conformation); may play a role in cardiomyocyte differentiation | 15: 85360691 |
| VENT homeobox (VENTX) | May function as a transcriptional repressor and influence mesodermal patterning and hemopoietic stem cell maintenance | 10: 135050326 |
| Lymphocyte antigen 6 complex, locus G5C (LY6G5C) | Located in the major histocompatibility complex (MHC) region on chromosome 6; may be involved in signal transduction or hematopoietic cell differentiation | 6: 31649619 |
| Primary ciliary dyskinesia protein 1 (PCDP1) | May function in ciliary motility | 2: 120301847 |
| Protein kinase, cGMP-dependent, type I (PRKG1) | Involved in signal transduction processes in diverse cell types; plays role in regulating cardiovascular and neuronal functions and in relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth | 10: 52833610 |
| MAP7 domain containing 2 (MAP7D2) | X-linked imprinted gene that may affect sex-specific brain function and/or sex-dependent neurobiological traits [50] | X: 20134719 |
| Carboxypeptidase M (CPM) | Associated with monocyte to macrophage differentiation; may play role in control of peptide hormone and growth factor activity at the cell surface and in the membrane-localized degradation of extracellular proteins | 12: 69346994 |
| Growth differentiation factor 1 (GDF1)/LAG1 longevity assurance homolog 1 (LASS1) | Member of TGF-beta superfamily; may function in regulation of cell growth and differentiation in embryonic and adult tissues and neural development in later embryogenesis; may be involved in aging | 19: 18981378 |
| Ubiquitin-like, containing PHD and RING finger domains, 1 (UHRF1) | Recruits a histone deacetylase to regulate gene expression; involved in G1/S transition and functions in the p53-dependent DNA damage checkpoint | 19: 4916593 |
| Anoctamin 3 (AN03) | May act as a calcium-activated chloride channel | 11: 26353723 |
| Homeobox protein Hox-A7 (HOXA7) | DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation | 7: 27196790 |
| Transmembrane protein 44 (TMEM44) | Enriched in the bottom portion of taste buds | 3: 194353554 |
| Potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1) | Voltage-gated potassium channel required for repolarization phase of the cardiac action potential; mutations associated with hereditary long QT syndrome 1, the Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation; exhibits tissue-specific imprinting; located in a region associated with the Beckwith-Wiedemann syndrome | 11: 2554583 |
| Polymerase I and transcript release factor 1 (PTRF) | Regulates rRNA transcription; thought to modify
lipid metabolism and insulin-regulated gene expression | 17: 40558063 |
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