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Obstetrics and Gynecology International
Volume 2009 (2009), Article ID 585269, 4 pages
Research Article

The Effect of Acid-Reducing Pharmacotherapy on the Severity of Nausea and Vomiting of Pregnancy

1The Motherisk Program, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8
2Department of Pharmacology, University of Toronto, Toronto, ON, Canada M5S 1A8

Received 1 October 2008; Revised 25 March 2009; Accepted 12 May 2009

Academic Editor: William A. Grobman

Copyright © 2009 Simerpal Kaur Gill et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Heartburn and acid reflux (HB/RF) are associated with increased severity of nausea and vomiting. The ability of acid-reducing drugs to reduce symptoms of nausea and vomiting of pregnancy has not been previously tested. Objective. To determine whether acid-reducing pharmacotherapy decreases the severity of NVP symptoms. Methods. We studied a cohort of women experiencing NVP, who were also experiencing HB/RF. Women were counseled to commence acid-reducing pharmacotherapy. The effectiveness of the acid-reducing medication in decreasing symptoms of both HB/RF and NVP was measured. Results. Acid-reducing drugs resulted in significant decreases in PUQE ( to , ) and well-being scores from the initial ( ) to the follow-up interview ( , ). After intervention with acid-reducing pharmacotherapy, a reduction in acid symptoms correlated significantly with reduction in NVP ( , ). Conclusion. This is the first study to demonstrate that management of HB/RF can reduce the severity of NVP.