Functional Role of P-Glycoprotein and Binding Protein Effect on the Placental Transfer of Lopinavir/Ritonavir in the Ex Vivo Human Perfusion Model

Figure 2

Variation of clearance index of lopinavir in the control and ciclosporin A phases (mean of values at 25, 30, 35, and 40 minutes versus 75, 80, 85, and 90 minutes) at low ((a), 10 g/L) and physiologic ((b), 30, and 40 g/L) albumin concentrations. The lines join the data from the same placenta (𝑛=3 at 10 g/L, 𝑛=3 at 30 g/L and 𝑛=5 at 40 g/L). Mean clearance index of lopinavir (0.401±0.058) with ciclosporin A (0.521±0.066) at 10 g/L (95% CI of the difference [−0.186,−0.054], 𝑃=.016) and 30 and 40 g/L (0.007±0.027 versus 0.072±0.101, 95% CI of the difference [−0.156,−0.002], 𝑃=.046).

(a)

(b)