Functional Role of P-Glycoprotein and Binding Protein Effect on the Placental Transfer of Lopinavir/Ritonavir in the Ex Vivo Human Perfusion Model

Table 1

Clearance index of lopinavir (A) and ritonavir (B) combination at steady state. (mean  ± SD). *means 𝑃≤.05

(a)

A	Control	Ciclosporin A	Relative increase in ClI
Albumin 10 g/L	0.401±0.058	0.521±0.065	×1.3*
Albumin 30 and 40 g/L	0.007±0.027	0.072±0.101	×10.29*

(b)

B	Control	Ciclosporin A	Relative increase in ClI
Albumin 10 g/L	0.06±0.104	0.104±0.181	×1.73
Albumin 30 and 40 g/L	0	0.071±0.103	—