Table 1

Agent Known effect on testis

CyclophosphamideSevere
Nitrogen mustardSevere
ProcarbazineSevere
BleomycinModerate
CarboplatinModerate
CisplatinModerate
CytarabineModerate
DoxorubicinModerate
EtoposideModerate
IfosfamideModerate
ThioguanineModerate
VinblastineModerate
VincristineModerate
MethotrexateMinimal

Effects are dose dependent.
Severe = Azoospermia shortly after treatement with less than 20% recovery of spermatogenesis.
Moderate = possible azoospermia shortly after treatment with 20–50% of patients recovering spermatogenesis.
Minimal = possibility of transient azoospermia but more than 50% of patients recovering spermatogenesis.