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Obstetrics and Gynecology International
Volume 2011, Article ID 358493, 9 pages
http://dx.doi.org/10.1155/2011/358493
Review Article

Ovarian Epithelial-Stromal Interactions: Role of Interleukins 1 and 6

1Department of Pathology & Cell Biology, MDC 11, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA
2H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA

Received 1 February 2011; Revised 12 April 2011; Accepted 27 April 2011

Academic Editor: Eddie Murta

Copyright © 2011 Kamisha T. Woolery and Patricia A. Kruk. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ovarian epithelial cancer is the most lethal gynecologic malignancy. The high mortality is attributed to the fact that most cases typically present in late stage when ovarian cancer (OC) has already spread beyond the ovary. Ovarian epithelial cancer cells are shed into intraperitoneal ascites and easily disseminate throughout the peritoneal cavity with preferential metastasis to the omentum, peritoneum, and local organs. Understanding how ovarian epithelial cells interact with and modulate their microenvironment can provide insight into the molecular mechanism(s) involved with malignant transformation and progression which may eventually identify novel diagnostic, prognostic, and therapeutic targets. The objective of this paper is to provide a brief consideration of ovarian surface epithelial-stromal interactions in regard to normal physiological function and tumor progression as influenced by two potentially key interleukins, interleukins-1 (IL-1) and -6 (IL-6), present in the microenvironment. Lastly, we will consider the clinical implications of IL-1 and IL-6 for OC patients.