Blocking Epidermal Growth Factor Receptor Signaling in HTR-8/SVneo First Trimester Trophoblast Cells Results in Dephosphorylation of PKB𝜶/AKT and Induces Apoptosis

Figure 5

EGF activated pathways in HTR-8sv/neo cells. EGF can signal through multiple pathways and ultimately influence many different downstream peptides. A major effect identified in these studies is through modulation of PKBα/AKT (bold).