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Obstetrics and Gynecology International
Volume 2012, Article ID 305025, 5 pages
Research Article

Ovarian Volume Correlates Strongly with the Number of Nongrowing Follicles in the Human Ovary

1School of Computer Science, University of St. Andrews, St. Andrews, Scotland, Kelsey KY16 9SX, UK
2Division of Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh, Scotland, Wallace EH9 1LW, UK

Received 5 August 2011; Revised 13 November 2011; Accepted 20 November 2011

Academic Editor: Neeta Singh

Copyright © 2012 Thomas W. Kelsey and W. Hamish B. Wallace. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A reliable indirect measure of ovarian reserve for the individual woman remains a challenge for reproductive specialists. Using descriptive statistics from a large-scale study of ovarian volumes, we have developed a normative model for healthy females for ages 25 through 85. For average values, this model has a strong and positive correlation () with our recent model of nongrowing follicles (NGFs) in the human ovary for ages 25 through 51. When both models are log-adjusted, the correlation increases to , over the full range of ovarian volume. Furthermore we can deduce that an ovary of 3 cm3 volume (or less) contains approximately 1000 NGF (or fewer). These strong correlations indicate that ovarian volume is a useful factor in the indirect estimation of human ovarian reserve for the individual woman.