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Obstetrics and Gynecology International
Volume 2012, Article ID 758508, 4 pages
http://dx.doi.org/10.1155/2012/758508
Clinical Study

Dosage Optimization for Letrozole Treatment in Clomiphene-Resistant Patients with Polycystic Ovary Syndrome: A Prospective Interventional Study

1School of Medicine, Bushehr University of Medical Sciences, Moallem Street, Bushehr, Iran
2Department of Obstetrics and Gynecology, Bushehr University of Medical Sciences, Moallem Street, Bushehr, Iran
3Department of Community Medicine, Bushehr University of Medical Sciences, Moallem Street, Bushehr, Iran

Received 30 July 2011; Revised 30 September 2011; Accepted 11 October 2011

Academic Editor: Lakhbir Dhaliwal

Copyright © 2012 Elham Rahmani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Dose adjustment for induction of ovulation is one of the most important problem. Methods. In a prospective interventional study, 44 clomiphene-resistant infertile patients (113 cycles) were selected from the Abolfazl Infertility Clinic of Bushehr University of Medical Sciences. Letrozole was given orally in a dose of 2.5 mg, 5 mg, and 7.5 mg, respectively. If the patient displayed no response, the dosage was increased. Results. In this patients ovulation occurred in 50 cycles (44.24%), clinical pregnancy rate according to number of cycles was 23.89% (27 of 113 cycles) and according to the number of patients was 61.36% (27 of 44 patients). In the 2.5, 5, and 7.5 groups, follicles occurred in 22.9%, 42.1%, and 85.18% of cycles, and pregnancy rate was 14.58%, 28.94% and, 33.33%, respectively. Conclusions. It is better to administer Letrozole at a lower dosage to prevent complications and increase the dose based on sonographic results antral follicular count, anti-Müllerian hormone, LH/FSH, and estradiol.