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Obstetrics and Gynecology International
Volume 2012, Article ID 851367, 5 pages
http://dx.doi.org/10.1155/2012/851367
Review Article

Endometrial Stem Cells and Reproduction

Department of Obstetrics, Gynecology and Women’s Health, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA

Received 7 September 2011; Revised 15 November 2011; Accepted 21 November 2011

Academic Editor: Sanjeev Sharma

Copyright © 2012 Sara S. Morelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Abnormal endometrial function remains a significant cause of implantation failure, recurrent pregnancy loss, and other pathologies responsible for female infertility. The development of novel therapies to treat infertility due to endometrial dysfunction requires an understanding of the latest advancements in endometrial cell biology, such as the role of endometrial stem cells. The remarkable regenerative capacity of the human endometrium is absolutely essential for successful reproduction and likely requires a population of stem cells in the endometrium. The purpose of this review is to provide an introduction to some of the newest concepts in endometrial stem cell biology.