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Obstetrics and Gynecology International
Volume 2013, Article ID 183024, 10 pages
http://dx.doi.org/10.1155/2013/183024
Review Article

The Role of Mitochondria from Mature Oocyte to Viable Blastocyst

OvaScience, Inc., 215 First Street, Suite 240, Cambridge, MA 02142, USA

Received 21 January 2013; Revised 23 April 2013; Accepted 29 April 2013

Academic Editor: Deborah A. Wing

Copyright © 2013 Scott Chappel. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [68 citations]

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  • Wilson B. M. de Paula, Ahmed-Noor A. Agip, Fanis Missirlis, Rachel Ashworth, Gema Vizcay-Barrena, Cathy H. Lucas, and John F. Allen, “Female and Male Gamete Mitochondria Are Distinct and Complementary in Transcription, Structure, and Genome Function,” Genome Biology and Evolution, vol. 5, no. 10, pp. 1969–1977, 2013. View at Publisher · View at Google Scholar
  • Moncef Benkhalifa, Yannick J. Ferreira, Hikmat Chahine, Noureddine Louanjli, Pierre Miron, Philippe Merviel, and Henri Copin, “MITOCHONDRIA: Participation to infertility as source of energy and cause of senescence,” The International Journal of Biochemistry & Cell Biology, 2014. View at Publisher · View at Google Scholar
  • M.H.C. Cruz, C.L.V. Leal, J.F. Cruz, D.X. Tan, and R.J. Reiter, “Essential actions of melatonin in protecting the ovary from oxidative damage,” Theriogenology, 2014. View at Publisher · View at Google Scholar
  • Juan J. Tarín, Miguel A. García-Pérez, and Antonio Cano, “Assisted reproductive technology results: Why are live-birth percentages so low?,” Molecular Reproduction and Development, 2014. View at Publisher · View at Google Scholar
  • Penny M. A. Kianian, and Shahryar F. Kianian, “Mitochondrial dynamics and the cell cycle,” Frontiers in Plant Science, vol. 5, 2014. View at Publisher · View at Google Scholar
  • Daniel A. Dumesic, David R. Meldrum, Mandy G. Katz-Jaffe, Rebecca L. Krisher, and William B. Schoolcraft, “Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health,” Fertility and Sterility, 2014. View at Publisher · View at Google Scholar
  • Heide Schatten, Qing-Yuan Sun, and Randall Prather, “The impact of mitochondrial function/dysfunction on IVF and new treatment possibilities for infertility,” Reproductive Biology And Endocrinology, vol. 12, pp. 1–11, 2014. View at Publisher · View at Google Scholar
  • Tayita Suttirojpattana, Tamas Somfai, Satoko Matoba, Takashi Nagai, Rangsun Parnpai, and Masaya Geshi, “The effect of temperature during liquid storage of in vitro matured bovine oocytes on subsequent embryo development,” Theriogenology, 2015. View at Publisher · View at Google Scholar
  • Kayla J. Perkel, Allison Tscherner, Casandra Merrill, Jonathan Lamarre, and Pavneesh Madan, “The ART of selecting the best embryo: A review of early embryonic mortality and bovine embryo viability assessment methods,” Molecular Reproduction and Development, 2015. View at Publisher · View at Google Scholar
  • Xing Duan, Xiao-Xin Dai, Teng Wang, Hong-Lin Liu, and Shao-Chen Sun, “Melamine negatively affects oocyte architecture, oocyte development and fertility in mice,” Human Reproduction, vol. 30, no. 7, pp. 1643–1652, 2015. View at Publisher · View at Google Scholar
  • Elnur Babayev, and Emre Seli, “Oocyte mitochondrial function and reproduction,” Current Opinion in Obstetrics and Gynecology, vol. 27, no. 3, pp. 175–181, 2015. View at Publisher · View at Google Scholar
  • Antonio Diez-Juan, Carmen Rubio, Carlos Marin, Sebastian Martinez, Nasser Al-Asmar, Marcia Riboldi, Patricia Díaz-Gimeno, Diana Valbuena, and Carlos Simón, “Mitochondrial DNA content as a viability score in human euploid embryos: less is better,” Fertility and Sterility, 2015. View at Publisher · View at Google Scholar
  • Mary Herbert, Dimitrios Kalleas, Daniel Cooney, Mahdi Lamb, and Lisa Lister, “Meiosis and Maternal Aging: Insights from Aneuploid Oocytes and Trisomy Births,” Cold Spring Harbor Perspectives In Biology, vol. 7, no. 4, 2015. View at Publisher · View at Google Scholar
  • Elpida Fragouli, and Dagan Wells, “Mitochondrial DNA Assessment to Determine Oocyte and Embryo Viability,” Seminars In Reproductive Medicine, vol. 33, no. 6, pp. 401–409, 2015. View at Publisher · View at Google Scholar
  • W. Karin Hendriks, Silvia Colleoni, Cesare Galli, Damien B. B. P. Paris, Ben Colenbrander, Bernard A. J. Roelen, and Tom A. E. Stout, “Maternal age and in vitro culture affect mitochondrial number and function in equine oocytes and embryos,” Reproduction, Fertility and Development, vol. 27, no. 6, pp. 957, 2015. View at Publisher · View at Google Scholar
  • Elena Silva, Alison F. Greene, Kevin Strauss, Jason R. Herrick, William B. Schoolcraft, and Rebecca L. Krisher, “Antioxidant supplementation during in vitro culture improves mitochondrial function and development of embryos from aged female mice,” Reproduction, Fertility and Development, vol. 27, no. 6, pp. 975, 2015. View at Publisher · View at Google Scholar
  • Jia-Jun Qiu, Zhao-Rui Ren, and Jing-Bin Yan, “Identification and functional analysis of long non-coding RNAs in human and mouse early embryos based on single-cell transcriptome data.,” Oncotarget, vol. 7, no. 38, pp. 61215–61228, 2016. View at Publisher · View at Google Scholar
  • Roger J. Hart, “Physiological aspects of female fertility: Role of the environment, modern lifestyle, and genetics,” Physiological Reviews, vol. 96, no. 3, pp. 873–909, 2016. View at Publisher · View at Google Scholar
  • Nathália A.S. Rocha-Frigoni, Beatriz C.S. Leão, Priscila Chediek Dall’Acqua, and Gisele Z. Mingoti, “Improving the cytoplasmic maturation of bovine oocytes matured in vitro with intra- and/or extracellular antioxidants is not associated with increased rates of embryo development,” Theriogenology, 2016. View at Publisher · View at Google Scholar
  • Lina Ghaloul-Gonzalez, Amy Goldstein, Catherine Walsh Vockley, Steven F. Dobrowolski, Amy Biery, Afifa Irani, Jordan Ibarra, D. Holmes Morton, Al-Walid Mohsen, and Jerry Vockley, “Mitochondrial respiratory chain disorders in the Old Order Amish population,” Molecular Genetics and Metabolism, 2016. View at Publisher · View at Google Scholar
  • Elnur Babayev, Tianren Wang, Klara Szigeti-Buck, Katie Lowther, Hugh S. Taylor, Tamas Horvath, and Emre Seli, “Reproductive aging is associated with changes in oocyte mitochondrial dynamics, function, and mtDNA quantity,” Maturitas, 2016. View at Publisher · View at Google Scholar
  • Terri L. Woodard, and Ewelina Bolcun-Filas, “Prolonging Reproductive Life after Cancer: The Need for Fertoprotective Therapies,” Trends in Cancer, 2016. View at Publisher · View at Google Scholar
  • Meenakshi Tiwari, and Shail K. Chaube, “Moderate increase of reactive oxygen species triggers meiotic resumption in rat follicular oocytes,” Journal of Obstetrics and Gynaecology Research, 2016. View at Publisher · View at Google Scholar
  • Elmira Hosseinzadeh, Saeed Zavareh, and Taghi Lashkarbolouki, “Antioxidant properties of coenzyme Q10-pretreated mouse pre-antral follicles derived from vitrified ovaries,” Journal of Obstetrics and Gynaecology Research, 2016. View at Publisher · View at Google Scholar
  • Manika Kala, Muhammad Vaseem Shaikh, and Manish Nivsarkar, “Equilibrium between anti-oxidants and reactive oxygen species: a requisite for oocyte development and maturation,” Reproductive Medicine and Biology, vol. 16, no. 1, pp. 28–35, 2016. View at Publisher · View at Google Scholar
  • T.L.B.G. Lins, A.Y.P. Cavalcante, J.M.S. Santos, V.G. Menezes, V.R.P. Barros, R.S. Barberino, M.É.S. Bezerra, T.J.S. Macedo, and M.H.T. Matos, “Rutin can replace the use of three other antioxidants in the culture medium, maintaining the viability of sheep isolated secondary follicles,” Theriogenology, 2016. View at Publisher · View at Google Scholar
  • Kyong Hee Choi, Sun Haw Hong, Hye Ran Lee, Hoon Taek Lee, Jae Ho Lee, and Sang Jin Lee, “Neogenin regulates mitochondrial activity in pre-implantation mouse embryos,” Biochemical and Biophysical Research Communications, 2016. View at Publisher · View at Google Scholar
  • David R. Meldrum, Robert F. Casper, Antonio Diez-Juan, Carlos Simon, Alice D. Domar, and Rene Frydman, “Aging and the environment affect gamete and embryo potential: can we intervene?,” Fertility and Sterility, 2016. View at Publisher · View at Google Scholar
  • Lucie Nemcova, Denisa Jansova, Katerina Vodickova-Kepkova, Petr Vodicka, Michal Jeseta, Marie Machatkova, and Jiri Kanka, “Detection of genes associated with developmental competence of bovine oocytes,” Animal Reproduction Science, 2016. View at Publisher · View at Google Scholar
  • Shu-Juan Wang, Wen-Ju Liu, Li-Ke Wang, Xun-Sheng Pang, and Li-Guo Yang, “The role of Melatonin receptor MTNR1A in the action of Melatonin on bovine granulosa cells,” Molecular Reproduction and Development, 2017. View at Publisher · View at Google Scholar
  • Guangyin Xi, Lei An, Zhenwei Jia, Kun Tan, Jiaxin Zhang, Zhuqing Wang, Chao Zhang, Kai Miao, Zhonghong Wu, and Jianhui Tian, “Natriuretic peptide receptor 2 (NPR2) localized in bovine oocyte underlies a unique mechanism for C-type natriuretic peptide (CNP)-induced meiotic arrest,” Theriogenology, 2017. View at Publisher · View at Google Scholar
  • Mehdi Vafaye Valleh, Nahid Karimi Zandi, Mikkel Aabech Rasmussen, and Poul Hyttel, “Optimal doses of EGF and GDNF act as biological response modifiers to improve porcine oocyte maturation and quality,” Zygote, vol. 25, no. 4, pp. 423–433, 2017. View at Publisher · View at Google Scholar
  • Jae-Hyun Ahn, Hyo-Jin Park, Jin-Woo Kim, Jae-Young Park, Soo-Yong Park, Seul-Gi Yang, Chang-Hyun Kim, Seung-Bin Yoon, Sun-Uk Kim, Kyu-Tae Chang, and Deog-Bon Koo, “Tyrphostin A9 improves blastocyst development in porcine embryos through induction of dynamin-related protein 1-dependent mitochondrial fission,” Mitochondrion, 2017. View at Publisher · View at Google Scholar
  • Victoria K. Gorshinova, Daria V. Tsvirkun, Iuliia A. Sukhanova, Nadezhda V. Tarasova, Maria A. Volodina, Maria V. Marey, Veronika U. Smolnikova, Mikhail Yu. Vysokikh, and Gennady T. Sukhikh, “Cumulus cell mitochondrial activity in relation to body mass index in women undergoing assisted reproductive therapy,” BBA Clinical, 2017. View at Publisher · View at Google Scholar
  • Zvi Roth, “Effect of Heat Stress on Reproduction in Dairy Cows: Insights into the Cellular and Molecular Responses of the Oocyte,” Annual Review of Animal Biosciences, vol. 5, no. 1, pp. 151–170, 2017. View at Publisher · View at Google Scholar
  • Tim Sanchez, Emily A. Seidler, David K. Gardner, Daniel Needleman, and Denny Sakkas, “Will noninvasive methods surpass invasive for assessing gametes and embryos?,” Fertility and Sterility, vol. 108, no. 5, pp. 730–737, 2017. View at Publisher · View at Google Scholar
  • Jason R. Herrick, Elena Silva, and Rebecca L. Krisher, “Production of Energy and Determination of Competence: Past Knowledge, Present Research, and Future Opportunities in Oocyte and Embryo Metabolism,” Animal Models and Human Reproduction, pp. 145–176, 2017. View at Publisher · View at Google Scholar
  • Bettina P. Mihalas, Kate A. Redgrove, Eileen A. McLaughlin, and Brett Nixon, “Molecular Mechanisms Responsible for Increased Vulnerability of the Ageing Oocyte to Oxidative Damage,” Oxidative Medicine and Cellular Longevity, vol. 2017, pp. 1–22, 2017. View at Publisher · View at Google Scholar
  • Jenna L. Lowe, Louise K. Bartolac, Roslyn Bathgate, and Christopher G. Grupen, “Cryotolerance of porcine blastocysts is improved by treating in vitro matured oocytes with L-carnitine prior to fertilization,” Journal of Reproduction and Development, vol. 63, no. 3, pp. 263–270, 2017. View at Publisher · View at Google Scholar
  • Marta Czernik, Paola Toschi, Federica Zacchini, Domenico Iuso, and Grażyna Ewa Ptak, “Deregulated Expression of Mitochondrial Proteins Mfn2 and Bcnl3L in Placentae from Sheep Somatic Cell Nuclear Transfer (SCNT) Conceptuses.,” PloS one, vol. 12, no. 1, 2017. View at Publisher · View at Google Scholar
  • Yumi Hoshino, “Updating the markers for oocyte quality evaluation: intracellular temperature as a new index,” Reproductive Medicine and Biology, vol. 17, no. 4, pp. 434–441, 2018. View at Publisher · View at Google Scholar
  • Zvi Roth, “Stress-induced alterations in oocyte transcripts are further expressed in the developing blastocyst,” Molecular Reproduction and Development, 2018. View at Publisher · View at Google Scholar
  • Sharon H. Anderson, Michael J. Glassner, Andrey Melnikov, Gary Friedman, and Zulfiya Orynbayeva, “Respirometric reserve capacity of cumulus cell mitochondria correlates with oocyte maturity,” Journal of Assisted Reproduction and Genetics, 2018. View at Publisher · View at Google Scholar
  • Pradeep Krishna Javvaji, Arindam Dhali, Joseph Rabinson Francis, Atul P. Kolte, Anjumoni Mech, L. Sathish, and Sudhir C. Roy, “Interleukin-7 improves in vitro maturation of ovine cumulus-oocyte complexes in a dose dependent manner,” Cytokine, 2018. View at Publisher · View at Google Scholar
  • Mary Herbert, “Oocyte Aneuploidy and the Maternal Age Effect,” Clinical Reproductive Science, pp. 133–145, 2018. View at Publisher · View at Google Scholar
  • Gustavo Nardini Cecchino, Emre Seli, Eduardo Leme Alves da Motta, and Juan Antonio García Velasco, “The role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights,” Reproductive BioMedicine Online, 2018. View at Publisher · View at Google Scholar
  • P. Comizzoli, E. E. Paulson, and L. K. McGinnis, “The mutual benefits of research in wild animal species and human-assisted reproduction,” Journal of Assisted Reproduction and Genetics, vol. 35, no. 4, pp. 551–560, 2018. View at Publisher · View at Google Scholar
  • Zvi Roth, “Reduction in oocyte developmental competence by stress is associated with alterations in mitochondrial function,” Journal of Dairy Science, 2018. View at Publisher · View at Google Scholar
  • B Lledo, J A Ortiz, R Morales, E García-Hernández, J Ten, A Bernabeu, J Llácer, and R Bernabeu, “Comprehensive mitochondrial DNA analysis and IVF outcome,” Human Reproduction Open, vol. 2018, no. 4, 2018. View at Publisher · View at Google Scholar
  • Rolando Pasquariello, Alison F Ermisch, Elena Silva, Sue McCormick, Deirdre Logsdon, Jennifer P Barfield, William B Schoolcraft, and Rebecca L Krisher, “Alterations in oocyte mitochondrial number and function are related to spindle defects and occur with maternal aging in mice and humans†,” Biology of Reproduction, 2018. View at Publisher · View at Google Scholar
  • Ying Jing, Li Li, Yuan-Yuan Li, Ying-Chun Ouyang, Qing-Yuan Sun, Cui-Lian Zhang, and Rong Li, “Embryo quality, and not chromosome nondiploidy, affects mitochondrial DNA content in mouse blastocysts,” Journal of Cellular Physiology, 2018. View at Publisher · View at Google Scholar
  • Manuel García-Herreros, Constantine A. Simintiras, and Patrick Lonergan, “Temporally differential protein expression of glycolytic and glycogenic enzymes during in vitro preimplantation bovine embryo development,” Reproduction, Fertility and Development, vol. 30, no. 9, pp. 1245, 2018. View at Publisher · View at Google Scholar
  • K. L. J. Desmet, W. F. A. Marei, I. Pintelon, P. E. J. Bols, and J. L. M. R. Leroy, “The effect of elevated non-esterified fatty acid concentrations on bovine spermatozoa and on oocyte in vitro fertilisation,” Reproduction, Fertility and Development, vol. 30, no. 11, pp. 1553, 2018. View at Publisher · View at Google Scholar
  • Jingshun Zhang, Yigang Bao, Xu Zhou, and Lianwen Zheng, “Polycystic ovary syndrome and mitochondrial dysfunction,” Reproductive Biology and Endocrinology, vol. 17, no. 1, 2019. View at Publisher · View at Google Scholar
  • Mauro Cozzolino, Diego Marin, and Giovanni Sisti, “New Frontiers in IVF: mtDNA and autologous germline mitochondrial energy transfer,” Reproductive Biology and Endocrinology, vol. 17, no. 1, 2019. View at Publisher · View at Google Scholar
  • Saif Ullah, Maoduo Zhang, Hao Yu, Sheeraz Mustafa, Muhammad Shafiq, Quanwei Wei, Wei Wang, Muhammad Jan, and Dagan Mao, “Heat exposure affected the reproductive performance of pregnant mice: Enhancement of autophagy and alteration of subcellular structure in the corpus luteum,” Reproductive Biology, 2019. View at Publisher · View at Google Scholar
  • J.M.S. Santos, A.P.O. Monte, T.L.B.G. Lins, R.S. Barberino, V.G. Menezes, B.B. Gouveia, T.J.S. Macedo, J.L. Oliveira Júnior, N.J. Donfack, and M.H.T. Matos, “Kaempferol can be used as the single antioxidant in the in vitro culture medium, stimulating sheep secondary follicle development through the phosphatidylinositol 3-kinase signaling pathway,” Theriogenology, 2019. View at Publisher · View at Google Scholar
  • Lucie Němcová, Pavlína Hulínská, Michal Ješeta, Bartosz Kempisty, Jiří Kaňka, and Marie Machatková, “Expression of selected mitochondrial genes during in vitro maturation of bovine oocytes related to their meiotic competence,” Theriogenology, 2019. View at Publisher · View at Google Scholar
  • Satoshi Ueno, Motoki Ito, Kazuo Uchiyama, Tadashi Okimura, Akiko Yabuuchi, Tamotsu Kobayashi, and Keiichi Kato, “Closed embryo culture system improved embryological and clinical outcome for single vitrified-warmed blastocyst transfer: A single-center large cohort study,” Reproductive Biology, 2019. View at Publisher · View at Google Scholar
  • Hao Ma, Kyle Martin, Doug Dixon, Alvaro G. Hernandez, and Gregory M. Weber, “Transcriptome analysis of egg viability in rainbow trout, Oncorhynchus mykiss,” BMC Genomics, vol. 20, no. 1, 2019. View at Publisher · View at Google Scholar
  • Soon-Jung Park, Ji-Heon Lee, Seul-Gi Lee, Jeoung Eun Lee, Joseph Seo, Jong Jin Choi, Taek-Hee Jung, Eun-Bin Chung, Ha Na Kim, Jongil Ju, Yun-Ho Song, Hyung-Min Chung, Dong Ryul Lee, and Sung-Hwan Moon, “Functional Equivalency in Human Somatic Cell Nuclear Transfer-Derived Endothelial Cells,” Stem Cells, 2019. View at Publisher · View at Google Scholar
  • Xiaoqiang Sheng, Yanjun Yang, Jianjun Zhou, Guijun Yan, Mengyuan Liu, Lu Xu, Zhongxun Li, Ruiwei Jiang, Zhenyu Diao, Xin Zhen, Lijun Ding, and Haixiang Sun, “Mitochondrial transfer from aged adipose-derived stem cells does not improve the quality of aged oocytes in C57BL/6 mice,” Molecular Reproduction and Development, 2019. View at Publisher · View at Google Scholar
  • Halimeh Mobarak, Mohammad Heidarpour, Pei-Shiue Jason Tsai, Aysa Rezabakhsh, Reza Rahbarghazi, Mohammad Nouri, and Mahdi Mahdipour, “Autologous mitochondrial microinjection; a strategy to improve the oocyte quality and subsequent reproductive outcome during aging,” Cell & Bioscience, vol. 9, no. 1, 2019. View at Publisher · View at Google Scholar
  • Elvira Matilla, Francisco Eduardo Martín-Cano, Lauro González-Fernández, Francisco Miguel Sánchez-Margallo, Ignacio Santiago Álvarez, and Beatriz Macías-García, “N-acetylcysteine addition after vitrification improves oocyte mitochondrial polarization status and the quality of embryos derived from vitrified murine oocytes,” BMC Veterinary Research, vol. 15, no. 1, 2019. View at Publisher · View at Google Scholar
  • Amy K. Schutt, Chellakkan S. Blesson, Jean W. Hsu, Cecilia T. Valdes, William E. Gibbons, Farook Jahoor, and Chandra Yallampalli, “Preovulatory exposure to a protein-restricted diet disrupts amino acid kinetics and alters mitochondrial structure and function in the rat oocyte and is partially rescued by folic acid,” Reproductive Biology and Endocrinology, vol. 17, no. 1, 2019. View at Publisher · View at Google Scholar
  • Maltese Giuseppa, Lepori Stefano, Sabatucci Ilaria, Tripodi Elisa, and Lorusso Domenica, “Capecitabine in patients with platinum-pretreated advanced or recurrent cervical carcinoma: a retrospective study,” International Journal of Gynecologic Cancer, pp. ijgc-2018-000085, 2019. View at Publisher · View at Google Scholar
  • Ayman Mesalam, Kyeong-Lim Lee, Imran Khan, M. M. R. Chowdhury, Shimin Zhang, Seok-Hwan Song, Myeong-Don Joo, Jae-Hoon Lee, Jong-In Jin, and Il-Keun Kong, “A combination of bovine serum albumin with insulin–transferrin–sodium selenite and/or epidermal growth factor as alternatives to fetal bovine serum in culture medium improves bovine embryo quality and trophoblast invasion by induction of matrix metalloproteinases,” Reproduction, Fertility and Development, vol. 31, no. 2, pp. 333, 2019. View at Publisher · View at Google Scholar
  • Rebecca L. Krisher, “Maternal age affects oocyte developmental potential at both ends of the age spectrum,” Reproduction, Fertility and Development, vol. 31, no. 1, pp. 1, 2019. View at Publisher · View at Google Scholar