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Obstetrics and Gynecology International
Volume 2013, Article ID 473289, 6 pages
Review Article

Is ICSI Risky?

1School of Women’s and Children’s Health, Faculty of Medicine, University of New South Wales, Randwick, NSW 2031, Australia
2Royal Hospital for Women, Randwick, NSW 2031, Australia

Received 25 October 2012; Accepted 26 January 2013

Academic Editor: Everett Magann

Copyright © 2013 May Y. W. Wong and William L. Ledger. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


As assisted reproductive technology (ART) methods become the mainstream of infertility treatment, it has become even more critical to reassess its safety. Following the results of a study published by the Robinson Institute in the New England Journal of Medicine, the risk of ART, especially intracytoplasmic sperm injection (ICSI), has never been so closely scrutinized. This paper traces the origins and development of ICSI, assesses the risks documented in the literature, and finally interprets the implications of the study for couples contemplating therapy. We support the need for continued vigilance towards ICSI and the importance in investigating male-factor infertility as a prequel to its use.