A Comparative Efficacy of Low-Dose Combined Oral Contraceptives Containing Desogestrel and Drospirenone in Premenstrual Symptoms

Table 4

The results of group and subgroup analyses according to the comparison of mean WHAQ scores changes between groups.

		Between groups
ANCOVA model
		Premenstrual			Menstrual			Postmenstrual
Mean WHAQ scores		DSG	DRSP	Sig	DSG	DRSP	Sig	DSG	DRSP	Sig
	Baseline	19.49 ± 6.76	21.33 ± 8.53	0.259	17.13 ± 5.88	17.42 ± 6.41	0.824	5.84 ± 1.98	6.16 ± 2.88	0.552
Total	3rd cycle	19.07 ± 6.27	14.78 ± 6.28	0.000	17.82 ± 6.11	12.98 ± 4.27	0.000	5.96 ± 2.04	4.80 ± 1.50	0.000
	6th cycle	16.24 ± 6.48	7.62 ± 2.46	0.000	15.40 ± 5.42	7.49 ± 2.87	0.000	5.38 ± 1.54	4.29 ± 0.82	0.000
	Baseline	7.76 ± 3.21	7.38 ± 3.77	0.610	7.16 ± 3.02	5.93 ± 3.20	0.066	1.51 ± 1.36	1.38 ± 1.48	0.657
Negative effect	3rd cycle	7.33 ± 2.95	5.07 ± 3.13	0.000	7.11 ± 2.99	4.36 ± 2.68	0.000	1.47 ± 1.38	0.80 ± 1.14	0.006
	6th cycle	5.60 ± 3.10	1.56 ± 1.52	0.000	5.67 ± 2.99	1.58 ± 1.34	0.000	1.13 ± 1.27	0.07 ± 0.33	0.000
	Baseline	4.71 ± 3.08	5.51 ± 3.61	0.261	2.87 ± 2.74	3.62 ± 2.90	0.208	0.36 ± 0.80	0.69 ± 1.18	0.121
Water retention	3rd cycle	4.51 ± 2.98	3.64 ± 2.39	0.000	3.51 ± 2.67	2.42 ± 1.83	0.000	0.56 ± 0.94	0.29 ± 0.66	0.005
	6th cycle	3.87 ± 2.37	1.98 ± 1.82	0.000	3.22 ± 2.32	1.33 ± 1.43	0.000	0.38 ± 0.61	0.16 ± 0.56	0.043
	Baseline	4.49 ± 3.29	5.84 ± 4.31	0.097	4.56 ± 3.17	5.27 ± 3.60	0.322	0.73 ± 0.96	0.87 ± 1.12	0.546
Impaired concentration	3rd cycle	4.11 ± 3.41	3.27 ± 3.11	0.000	3.96 ± 2.90	3.02 ± 2.34	0.000	0.62 ± 0.94	0.36 ± 0.68	0.063
	6th cycle	3.27 ± 3.14	0.93 ± 1.10	0.000	3.20 ± 2.70	1.11 ± 1.49	0.000	0.38 ± 0.86	0.04 ± 0.30	0.013
	Baseline	1.84 ± 1.63	2.09 ± 1.47	0.457	1.53 ± 1.34	1.80 ± 1.29	0.339	0.18 ± 0.54	0.27 ± 0.58	0.452
Increased appetite	3rd cycle	1.96 ± 1.36	1.33 ± 1.07	0.000	1.58 ± 1.20	1.11 ± 0.96	0.000	0.36 ± 0.57	0.11 ± 0.32	0.007
	6th cycle	2.04 ± 1.28	1.07 ± 1.03	0.000	1.38 ± 1.15	0.62 ± 0.86	0.000	0.24 ± 0.48	0.11 ± 0.38	0.167
	Baseline	0.64 ± 0.83	0.51 ± 0.63	0.392	1.04 ± 0.85	0.80 ± 0.79	0.161	3.02 ± 0.66	2.96 ± 0.64	0.626
Feeling of well being	3rd cycle	1.11 ± 0.91	1.47 ± 0.73	0.008	1.62 ± 0.75	2.07 ± 1.01	0.002	2.91 ± 0.76	3.24 ± 0.86	0.042
	6th cycle	1.42 ± 0.81	2.09 ± 0.67	0.000	1.89 ± 0.83	2.78 ± 0.67	0.000	3.20 ± 0.76	3.91 ± 0.29	0.000
	Baseline	0.04 ± 0.30	0.00 ± 0.00	0.320	0.04 ± 0.30	0.00 ± 0.00	0.320	0.04 ± 0.30	0.00 ± 0.00	0.320
Undesirable hair changes	3rd cycle	0.04 ± 0.30	0.00 ± 0.00	1.000	0.04 ± 0.30	0.00 ± 0.00	1.000	0.04 ± 0.30	0.00 ± 0.00	1.000
	6th cycle	0.04 ± 0.30	0.00 ± 0.00	1.000	0.04 ± 0.30	0.00 ± 0.00	1.000	0.04 ± 0.30	0.00 ± 0.00	1.000

DSG: desogestrel and DRSP: drospirenone.