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Obstetrics and Gynecology International
Volume 2013, Article ID 583891, 11 pages
http://dx.doi.org/10.1155/2013/583891
Review Article

Contemporary Clinical Management of Endometrial Cancer

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, 161 Fort Washington Avenue, HIP 8-838, New York, NY 10032, USA

Received 24 April 2013; Accepted 28 May 2013

Academic Editor: Donghai Dai

Copyright © 2013 Helen E. Dinkelspiel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. American Cancer Society, Cancer Facts & Figures, American Cancer Society, New York, NY, USA, 2012.
  2. “SEER Cancer Statistics Review, 1975–2008,” National Cancer Institute, 2011, http://seer.cancer.gov/csr/1975_2008/.
  3. D. W. Cramer, “The epidemiology of endometrial and ovarian cancer,” Hematology/Oncology Clinics of North America, vol. 26, no. 1, pp. 1–12, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. R. M. Merrill, “Impact of hysterectomy and bilateral oophorectomy on race-specific rates of corpus, cervical, and ovarian cancers in the United States,” Annals of Epidemiology, vol. 16, no. 12, pp. 880–887, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. National Comprehensive Cancer Network I, NCCN Guidelines Uterine Neoplasms. Version 2, 2012.
  6. K. M. Flegal, D. Carroll, B. K. Kit, and C. L. Ogden, “Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010,” Journal of the American Medical Association, vol. 307, no. 5, pp. 491–497, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Economist, http://www.economist.com/blogs/dailychart/2011/08/emerging-vs-developed-economies.
  8. J. Ferlay, H. Shin, F. Bray, D. Forman, C. Mathers, and D. M. Parkin, “Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008,” International Journal of Cancer, vol. 127, no. 12, pp. 2893–2917, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. M. A. Voss, R. Ganesan, L. Ludeman et al., “Should grade 3 endometrioid endometrial carcinoma be considered a type 2 cancer—a clinical and pathological evaluation,” Gynecologic Oncology, vol. 124, no. 1, pp. 15–20, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. R. E. Schmandt, D. A. Iglesias, N. N. Co, and K. H. Lu, “Understanding obesity and endometrial cancer risk: opportunities for prevention,” American Journal of Obstetrics and Gynecology, vol. 205, no. 6, pp. 518–525, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. E. E. Calle and R. Kaaks, “Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms,” Nature Reviews Cancer, vol. 4, no. 8, pp. 579–591, 2004. View at Google Scholar · View at Scopus
  12. C. M. Friedenreich, L. S. Cook, A. M. Magliocco, M. A. Duggan, and K. S. Courneya, “Case-control study of lifetime total physical activity and endometrial cancer risk,” Cancer Causes and Control, vol. 21, no. 7, pp. 1105–1116, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Dossus, N. Allen, R. Kaaks et al., “Reproductive risk factors and endometrial cancer: the European prospective investigation into cancer and nutrition,” International Journal of Cancer, vol. 127, no. 2, pp. 442–451, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. K. S. Tewari and B. J. Monk, “American society of clinical oncology 2011 annual meeting update: summary of selected gynecologic cancer abstracts,” Gynecologic Oncology, vol. 122, no. 2, pp. 209–212, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. R. Pilarski, “Cowden syndrome: a critical review of the clinical literature,” Journal of Genetic Counseling, vol. 18, no. 1, pp. 13–27, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. V. Beral, D. Bull, and G. Reeves, “Million Women Study C. Endometrial cancer and hormone-replacement therapy in the Million Women Study,” The Lancet, vol. 365, no. 9470, pp. 1543–1551, 2005. View at Google Scholar
  17. S. Karageorgi, M. A. Gates, S. E. Hankinson, and I. De Vivo, “Perineal use of talcum powder and endometrial cancer risk,” Cancer Epidemiology Biomarkers and Prevention, vol. 19, no. 5, pp. 1269–1275, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. E. M. John, J. Koo, and P. L. Horn-Ross, “Lifetime physical activity and risk of endometrial cancer,” Cancer Epidemiology Biomarkers and Prevention, vol. 19, no. 5, pp. 1276–1283, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Arem, M. L. Irwin, Y. Zhou, L. Lu, H. Risch, and H. Yu, “Physical activity and endometrial cancer in a population-based case-control study,” Cancer Causes and Control, vol. 22, no. 2, pp. 219–226, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. K. A. Rosenblatt, D. B. Thomas, G. Berry et al., “Prolonged lactation and endometrial cancer,” International Journal of Epidemiology, vol. 24, no. 3, pp. 499–503, 1995. View at Google Scholar · View at Scopus
  21. R. M. Beining, L. K. Dennis, E. M. Smith, and A. Dokras, “Meta-analysis of intrauterine device use and risk of endometrial cancer,” Annals of Epidemiology, vol. 18, no. 6, pp. 492–499, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. J. V. Lacey Jr., L. A. Brinton, R. Mortel et al., “Tubal sterilization and risk of cancer of the endometrium,” Gynecologic Oncology, vol. 79, no. 3, pp. 482–484, 2000. View at Publisher · View at Google Scholar · View at Scopus
  23. P. D. Terry, T. E. Rohan, S. Franceschi, and E. Weiderpass, “Cigarette smoking and the risk of endometrial cancer,” The Lancet Oncology, vol. 3, no. 8, pp. 470–480, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Bernatsky, R. Ramsey-Goldman, W. D. Foulkes, C. Gordon, and A. E. Clarke, “Breast, ovarian, and endometrial malignancies in systemic lupus erythematosus: a meta-analysis,” British Journal of Cancer, vol. 104, no. 9, pp. 1478–1481, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. E. W. Cooke, L. Pappas, and D. K. Gaffney, “Does the revised International Federation of Gynecology and Obstetrics staging system for endometrial cancer lead to increased discrimination in patient outcomes?” Cancer, vol. 117, no. 18, pp. 4231–4237, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. S. N. Lewin, T. J. Herzog, N. I. B. Medel et al., “Comparative performance of the 2009 international federation of gynecology and Obstetrics' staging system for uterine corpus cancer,” Obstetrics and Gynecology, vol. 116, no. 5, pp. 1141–1149, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. B. R. Page, L. Pappas, E. W. Cooke, and D. K. Gaffney, “Does the FIGO, 2009 endometrial cancer staging system more accurately correlate with clinical outcome in different histologies? Revised staging, endometrial cancer, histology,” International Journal of Gynecological Cancer, vol. 22, no. 4, pp. 593–598, 2012. View at Google Scholar
  28. M. Ballester, G. Dubernard, F. Lécuru et al., “Detection rate and diagnostic accuracy of sentinel-node biopsy in early stage endometrial cancer: a prospective multicentre study (SENTI-ENDO),” The Lancet Oncology, vol. 12, no. 5, pp. 469–476, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. G. S. Huang, J. S. Gebb, M. H. Einstein, S. Shahabi, A. P. Novetsky, and G. L. Goldberg, “Accuracy of preoperative endometrial sampling for the detection of high-grade endometrial tumors,” American Journal of Obstetrics and Gynecology, vol. 196, no. 3, pp. 243.e1–243.e5, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. T. J. Dubinsky, “Value of sonography in the diagnosis of abnormal vaginal bleeding,” Journal of Clinical Ultrasound, vol. 32, no. 7, pp. 348–353, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Bingol, Z. Gunenc, A. Gedikbasi, H. Guner, S. Tasdemir, and B. Tiras, “Comparison of diagnostic accuracy of saline infusion sonohysterography, transvaginal sonography and hysteroscopy,” Journal of Obstetrics and Gynaecology, vol. 31, no. 1, pp. 54–58, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. M. F. K. Fung, A. Reid, W. Faught et al., “Prospective longitudinal study of ultrasound screening for endometrial abnormalities in women with breast cancer receiving tamoxifen,” Gynecologic Oncology, vol. 91, no. 1, pp. 154–159, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. W. T. Creasman, C. P. Morrow, B. N. Bundy, H. D. Homesley, J. E. Graham, and P. B. Heller, “Surgical pathologic spread patterns of endometrial cancer. A gynecologic oncology group study,” Cancer, vol. 60, supplement 8, pp. 2035–2041, 1987. View at Google Scholar · View at Scopus
  34. C. L. Creutzberg, “Lymphadenectomy in apparent early-stage endometrial carcinoma: do numbers count?” Journal of Clinical Oncology, vol. 23, no. 16, pp. 3653–3655, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. N. Kadar, J. H. Malfetano, and H. D. Homesley, “Determinants of survival of surgically staged patients with endometrial carcinoma histologically confined to the uterus: implications for therapy,” Obstetrics and Gynecology, vol. 80, no. 4, pp. 655–659, 1992. View at Google Scholar · View at Scopus
  36. C. P. Morrow, B. N. Bundy, R. J. Kurman et al., “Relationship between surgical-pathological risk factors and outcome in clinical stage I and II carcinoma of the endometrium: a gynecologic oncology group study,” Gynecologic Oncology, vol. 40, no. 1, pp. 55–65, 1991. View at Publisher · View at Google Scholar · View at Scopus
  37. P. B. Panici, S. Basile, F. Maneschi et al., “Systematic pelvic lymphadenectomy vs no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial,” Journal of the National Cancer Institute, vol. 100, no. 23, pp. 1707–1716, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. H. Kitchener, A. M. Swart, Q. Qian, C. Amos, and M. K. Parmar, “Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study,” The Lancet, vol. 373, no. 9658, pp. 125–136, 2009. View at Google Scholar
  39. W. T. Creasman, D. E. Mutch, and T. J. Herzog, “ASTEC lymphadenectomy and radiation therapy studies: are conclusions valid?” Gynecologic Oncology, vol. 116, no. 3, pp. 293–294, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. J. K. Chan, M. K. Cheung, W. K. Huh et al., “Therapeutic role of lymph node resection in endometrioid corpus cancer: a study of 12,333 patients,” Cancer, vol. 107, no. 8, pp. 1823–1830, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. A. Mariani, S. C. Dowdy, W. A. Cliby et al., “Prospective assessment of lymphatic dissemination in endometrial cancer: a paradigm shift in surgical staging,” Gynecologic Oncology, vol. 109, no. 1, pp. 11–18, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. S. C. Dowdy, B. J. Borah, J. N. Bakkum-Gamez et al., “Prospective assessment of survival, morbidity, and cost associated with lymphadenectomy in low-risk endometrial cancer,” Gynecologic Oncology, vol. 127, no. 1, pp. 5–10, 2012. View at Google Scholar
  43. R. E. Bristow, M. L. Zahurak, C. J. Alexander, R. C. Zellars, and F. J. Montz, “FIGO stage IIIC endometrial carcinoma: resection of macroscopic nodal disease and other determinants of survival,” International Journal of Gynecological Cancer, vol. 13, no. 5, pp. 664–672, 2003. View at Publisher · View at Google Scholar · View at Scopus
  44. C. Fotopoulou, K. Savvatis, R. Kraetschell, J. C. Schefold, W. Lichtenegger, and J. Sehouli, “Systematic pelvic and aortic lymphadenectomy in intermediate and high-risk endometrial cancer: lymph-node mapping and identification of predictive factors for lymph-node status,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 149, no. 2, pp. 199–203, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. J. Cardenas-Goicoechea, E. Soto, L. Chuang, H. Gretz, and T. C. Randall, “Integration of robotics into two established programs of minimally invasive surgery for endometrial cancer appears to decrease surgical complications,” Journal of Gynecologic Oncology, vol. 24, no. 1, pp. 21–28, 2013. View at Google Scholar
  46. J. Orr Jr., J. L. Holimon, P. F. Orr, J. J. Mikuta, and W. T. Creasman, “Stage I corpus cancer: is teletherapy necessary?” American Journal of Obstetrics and Gynecology, vol. 176, no. 4, pp. 777–789, 1997. View at Google Scholar · View at Scopus
  47. A. Mariani, S. C. Dowdy, W. A. Cliby et al., “Efficacy of systematic lymphadenectomy and adjuvant radiotherapy in node-positive endometrial cancer patients,” Gynecologic Oncology, vol. 101, no. 2, pp. 200–208, 2006. View at Publisher · View at Google Scholar · View at Scopus
  48. F. Khoury-Collado, G. E. Glaser, O. Zivanovic et al., “Improving sentinel lymph node detection rates in endometrial cancer: how many cases are needed?” Gynecologic Oncology, vol. 115, no. 3, pp. 453–455, 2009. View at Publisher · View at Google Scholar · View at Scopus
  49. J. L. Walker, M. R. Piedmonte, N. M. Spirtos et al., “Recurrence and survival after random assignment to laparoscopy versus laparotomy for comprehensive surgical staging of uterine cancer: gynecologic oncology group LAP2 study,” Journal of Clinical Oncology, vol. 30, no. 7, pp. 695–700, 2012. View at Publisher · View at Google Scholar · View at Scopus
  50. J. L. Walker, M. R. Piedmonte, N. M. Spirtos et al., “Laparoscopy compared with laparotomy for comprehensive surgical staging of uterine cancer: gynecologic oncology group Study LAP2,” Journal of Clinical Oncology, vol. 27, no. 32, pp. 5331–5336, 2009. View at Publisher · View at Google Scholar · View at Scopus
  51. J. F. Boggess, P. A. Gehrig, L. Cantrell et al., “A comparative study of 3 surgical methods for hysterectomy with staging for endometrial cancer: robotic assistance, laparoscopy, laparotomy,” American Journal of Obstetrics and Gynecology, vol. 199, no. 4, pp. 360.e1–360.e9, 2008. View at Publisher · View at Google Scholar · View at Scopus
  52. J. D. Wright, W. M. Burke, E. T. Wilde et al., “Comparative effectiveness of robotic versus laparoscopic hysterectomy for endometrial cancer,” Journal of Clinical Oncology, vol. 30, no. 8, pp. 783–791, 2012. View at Publisher · View at Google Scholar · View at Scopus
  53. J. D. Wright, A. M. Buck, M. Shah, W. M. Burke, P. B. Schiff, and T. J. Herzog, “Safety of ovarian preservation in premenopausal women with endometrial cancer,” Journal of Clinical Oncology, vol. 27, no. 8, pp. 1214–1219, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. K. Ushijima, H. Yahata, H. Yoshikawa et al., “Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women,” Journal of Clinical Oncology, vol. 25, no. 19, pp. 2798–2803, 2007. View at Publisher · View at Google Scholar · View at Scopus
  55. I. Podzielinski, M. E. Randall, P. J. Breheny et al., “Primary radiation therapy for medically inoperable patients with clinical stage i and II endometrial carcinoma,” Gynecologic Oncology, vol. 124, no. 1, pp. 36–41, 2012. View at Publisher · View at Google Scholar · View at Scopus
  56. C. L. Creutzberg, W. L. J. van Putten, P. C. M. Koper et al., “Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial,” The Lancet, vol. 355, no. 9213, pp. 1404–1411, 2000. View at Google Scholar · View at Scopus
  57. J. Aalders, V. Abeler, P. Kolstad, and M. Onsrud, “Postoperative external irradiation and prognostic parameters in stage I endometrial carcinoma. Clinical and histopathologic study of 540 patients,” Obstetrics and Gynecology, vol. 56, no. 4, pp. 419–427, 1980. View at Google Scholar · View at Scopus
  58. H. M. Keys, J. A. Roberts, V. L. Brunetto et al., “A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a gynecologic oncology group study,” Gynecologic Oncology, vol. 92, no. 3, pp. 744–751, 2004. View at Publisher · View at Google Scholar · View at Scopus
  59. P. Blake, A. M. Swart, J. Orton et al., “Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN. 5 randomised trials): pooled trial results, systematic review, and meta-analysis,” The Lancet, vol. 373, no. 9658, pp. 137–146, 2009. View at Google Scholar
  60. A. Kong, N. Johnson, P. Cornes et al., “Adjuvant radiotherapy for stage I endometrial cancer,” Cochrane Database of Systematic Reviews, no. 2, Article ID CD003916, 2007. View at Google Scholar · View at Scopus
  61. C. M. Lee, A. Szabo, D. C. Shrieve, O. K. Macdonald, and D. K. Gaffney, “Frequency and effect of adjuvant radiation therapy among women with stage I endometrial adenocarcinoma,” Journal of the American Medical Association, vol. 295, no. 4, pp. 389–397, 2006. View at Publisher · View at Google Scholar · View at Scopus
  62. http://www.nccn.org/professionals/physician_gls/pdf/uterine.pdf.
  63. R. Nout, V. Smit, H. Putter et al., “Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial,” The Lancet, vol. 375, no. 9717, pp. 816–823, 2010. View at Publisher · View at Google Scholar · View at Scopus
  64. M. E. Randall, V. L. Filiaci, H. Muss et al., “Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a gynecologic oncology group study,” Journal of Clinical Oncology, vol. 24, no. 1, pp. 36–44, 2006. View at Publisher · View at Google Scholar · View at Scopus
  65. R. Maggi, A. Lissoni, F. Spina et al., “Adjuvant chemotherapy vs radiotherapy in high-risk endometrial carcinoma: results of a randomised trial,” British Journal of Cancer, vol. 95, no. 3, pp. 266–271, 2006. View at Publisher · View at Google Scholar · View at Scopus
  66. N. Susumu, S. Sagae, Y. Udagawa et al., “Randomized phase III trial of pelvic radiotherapy versus cisplatin-based combined chemotherapy in patients with intermediate- and high-risk endometrial cancer: a Japanese gynecologic oncology group study,” Gynecologic Oncology, vol. 108, no. 1, pp. 226–233, 2008. View at Publisher · View at Google Scholar · View at Scopus
  67. T. Hogberg, M. Signorelli, C. F. De Oliveira et al., “Sequential adjuvant chemotherapy and radiotherapy in endometrial cancer—results from two randomised studies,” European Journal of Cancer, vol. 46, no. 13, pp. 2422–2431, 2010. View at Publisher · View at Google Scholar · View at Scopus
  68. H. D. Homesley, V. Filiaci, S. K. Gibbons et al., “A randomized phase III trial in advanced endometrial carcinoma of surgery and volume directed radiation followed by cisplatin and doxorubicin with or without paclitaxel: a gynecologic oncology group study,” Gynecologic Oncology, vol. 112, no. 3, pp. 543–552, 2009. View at Publisher · View at Google Scholar · View at Scopus
  69. M. E. Randall, V. L. Filiaci, H. Muss et al., “Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a gynecologic oncology group study,” Journal of Clinical Oncology, vol. 24, no. 1, pp. 36–44, 2006. View at Publisher · View at Google Scholar · View at Scopus
  70. M. A. Sovak, M. L. Hensley, J. Dupont et al., “Paclitaxel and carboplatin in the adjuvant treatment of patients with high-risk stage III and IV endometrial cancer: a retrospective study,” Gynecologic Oncology, vol. 103, no. 2, pp. 451–457, 2006. View at Publisher · View at Google Scholar · View at Scopus
  71. A. A. Secord, L. J. Havrilesky, D. M. O'Malley et al., “A multicenter evaluation of sequential multimodality therapy and clinical outcome for the treatment of advanced endometrial cancer,” Gynecologic Oncology, vol. 114, no. 3, pp. 442–447, 2009. View at Publisher · View at Google Scholar · View at Scopus
  72. W. K. Huh, J. M. Straughn Jr., A. Mariani et al., “Salvage of isolated vaginal recurrences in women with surgical stage I endometrial cancer: a multiinstitutional experience,” International Journal of Gynecological Cancer, vol. 17, no. 4, pp. 886–889, 2007. View at Publisher · View at Google Scholar · View at Scopus
  73. T. J. Herzog, “What is the clinical value of adding tamoxifen to progestins in the treament of advanced or recurrent endometrial cancer?” Gynecologic Oncology, vol. 92, no. 1, pp. 1–3, 2004. View at Publisher · View at Google Scholar · View at Scopus
  74. A. M. Oza, L. Elit, M. Tsao et al., “Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: a trial of the NCIC Clinical Trials Group,” Journal of Clinical Oncology, vol. 29, no. 24, pp. 3278–3285, 2011. View at Publisher · View at Google Scholar · View at Scopus