Contemporary Clinical Management of Endometrial Cancer

Table 5

Randomized trials of adjuvant radiation therapy in early-stage endometrial cancer.

Trial	Norwegian trial	PORTEC-1	GOG-99	ASTEC/EN 5
Authors	Aalders et al.	Creutzberg et al.	Keys et al.	ASTEC/EN 5 Study Group et al.
Endometrial cancer stage	I	I, grade 1, 2, 3	IB, IC, II	I, IIA
Number of patients	540	715	392	905
Adjuvant treatment	Vaginal brachytherapy (VBT) versus VBT and pelvic radiation therapy (RT)	Observation versus RT	Observation versus RT	Observation versus RT
Vaginal and pelvic recurrence	7% versus 2% (𝑃<0.01)	14% versus 4% (𝑃<0.001)	12% versus 3%	6% versus 3%
Overall survival	89% versus 91%	85% versus 81% (𝑃=0.31)	86% versus 92% (𝑃=0.557)	84% versus 84%
Extent of staging	Staging not mandated	Staging not mandated	Staging mandated	50% staged