Review Article
Contemporary Clinical Management of Endometrial Cancer
Table 5
Randomized trials of adjuvant radiation therapy in early-stage endometrial cancer.
| Trial | Norwegian trial | PORTEC-1 | GOG-99 | ASTEC/EN 5 |
| Authors | Aalders et al. | Creutzberg et al. | Keys et al. | ASTEC/EN 5 Study Group et al. | Endometrial cancer stage | I | I, grade 1, 2, 3 | IB, IC, II | I, IIA | Number of patients | | | | | Adjuvant treatment | Vaginal brachytherapy (VBT) versus VBT and pelvic radiation therapy (RT) | Observation versus RT | Observation versus RT | Observation versus RT | Vaginal and pelvic recurrence | 7% versus 2% () | 14% versus 4% () | 12% versus 3% | 6% versus 3% | Overall survival | 89% versus 91% | 85% versus 81% () | 86% versus 92% () | 84% versus 84% | Extent of staging | Staging not mandated | Staging not mandated | Staging mandated | 50% staged |
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